趋化因子与哺乳动物生殖  

The Role of Chemokines in Mammalian Reproduction

作　　者：霍立军[1] 杨增明[1] 

机构地区：[1]东北农业大学生命科学学院,哈尔滨150030

出　　处：《动物学杂志》2003年第2期96-100,共5页Chinese Journal of Zoology

基　　金：国家杰出青年科学基金项目资助 (No.3982 5 12 0 )

摘　　要：趋化因子 (chemokine)通过其G蛋白偶联的受体介导白细胞在各种组织内迁移。最近发现 ,白细胞介素 8(IL 8)、单核细胞趋化蛋白 1 (MCP 1 )、调节激活的正常T细胞表达和分泌的蛋白 (RANTES)、调节生长的原癌基因α(GRO α)、粒细胞趋化蛋白 2 (GCP 2 )等趋化因子在卵泡发育、闭锁、排卵、类固醇激素生成、黄体功能、月经周期、着床、子宫颈成熟、早产和子宫内膜异位症等生殖过程中具有重要的调节作用。Chemokines mediate leukocyte migration in various tissues through their G protein|coupled receptors. Recent findings show that chemokines, including interleukin|8 (IL|8), monocyte chemotactic protein|1 (MCP|1), regulated on activation normal T cell|expressed and secreted protein (RANTES), growth|regulated oncogene|α(GRO|α), and granulocyte chemotactic peptide|2 (GCP|2), are closely involved in reproductive processes like follicular development and atresia, ovulation, steroidogenesis, corpus luteum function, menstruation, implantation, cervical ripening, preterm labor and endometriosis.

关 键 词：趋化因子 哺乳动物 生殖 白细胞 迁移 作用机理 排卵 黄体功能 胚胎着床 

分 类 号：Q492[生物学—生理学]