白细胞介素2对大鼠心肌主动及被动电特性的影响  

Effects of interleukin 2 on the active and passive electrical charaeteristics of rat papillary muscles

作　　者：林国华[1] 夏强[2] 

机构地区：[1]杭州医学高等专科学校生理教研室,浙江杭州310012 [2]浙江大学医学院生理教研室,浙江杭州310006

出　　处：《中国现代应用药学》2003年第2期106-107,共2页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省自然科学基金青年人才专项资金资助 (NoRC990 38)

摘　　要：目的　了解白细胞介素对心脏电特性的影响。方法　在大鼠右心室乳头肌标本上 ,用玻璃微电极技术 ,观察白细胞介素 2 (IL 2 )对心肌动作电位和被动电特性的影响。结果　IL 2使心肌动作电位时程 (APD50 和APD80 )缩短 ,对静息电位、动作电位幅度和 0期去极化最大速度无显著作用 ;IL 2引起乳头肌心肌细胞空间常数和时间常数增加 ,细胞内阻降低。结论　IL 2可改变大鼠心肌的主。OBJECTIVE AND METHOD Effects of interleukin 2 (IL 2) on the action potential and passive electrical charaeteristics were studied in isolated rat papillary muscles by microelectrode technique. RESULTS IL 2 reduced the action potential duration (APD 50 and APD 80 ) of the papillary muscles, but did not affect the resting potential, action potential and maximal velocity of depolarization. IL 2 increased the membrane space and time constants, and decreased internal longitudinal resistance. CONCLUSION IL 2 changed the active and passive electrical properties of rat papillary muscles.

关 键 词：白细胞介素2 心室乳头肌 玻璃微电极技术 动作电位 被动电特性 

分 类 号：R979.5[医药卫生—药品] R541[医药卫生—药学]