慢性乙型肝炎患者远期生存质量研究  

Long-term health-related quality of life in chronic hepatitis B patients

作　　者：巫贵成[1] 周卫平[1] 赵有蓉[1] 郭树华[1] 王志毅[1] 邹淑碧[1] 张全海[1] 任红[1] 黄爱龙[1] 张定凤[1] 

机构地区：[1]重庆医科大学病毒性肝炎研究所,400010

出　　处：《中华肝脏病杂志》2003年第5期275-277,共3页Chinese Journal of Hepatology

基　　金：中青年肝病科研基金

摘　　要：目的 对慢性乙型肝炎患者远期生存质量进行研究,为其预后判断,药物疗效的分析及药品经济学评估提供依据。 方法 采用补充修订的SF-36健康相关生存质量量表调查101例6～l 8年前经肝穿活组织检查诊断的慢性乙型肝炎和105例门诊体检的普通人群。 结果 慢性乙型肝炎患者在生理机能、生理职能、总体健康、精神健康、肝病特有症状5个方面的远期生存质量低于普通人群,差异有显著性(μ≥2.10,P<0.05)。 结论 慢性乙型肝炎患者远期生存质量差。Objective To evaluate their long-term outcome and the efficacy and economic significance of antiviral drugs by investigating the long-term health-related quality of life (HQL) in chronic hepatitis B (CHB) patients. Methods The HQL of 101 CHB patients with biopsy-proven 6-18 years ago and 105 persons of general population as control was studied with revised SF-36 questionnaire. Results The HQL in CHB patients was lower than that in general population in physical functioning, role physical, general health, mental health, and specific symptoms (μ≥ 2.10, P < 0.05). Conclusion The long-term HQL in chronic hepatitis B patients is poor.

关 键 词：慢性 乙型肝炎 远期 生存质量 研究 

分 类 号：R512.62[医药卫生—内科学]