桑黄对四氯化碳致大鼠肝损伤的保护作用  

Protective Effect of Phellinus Igniarius on CCl 4 -induced Liver Injury in Rats

作　　者：张万国[1] 胡晋红[1] 蔡溱[1] 黄瑾[1] 

机构地区：[1]第二军医大学长海医院药学部,上海市200433

出　　处：《中国药房》2003年第5期267-269,共3页China Pharmacy

摘　　要：目的 :研究桑黄对肝损伤的保护作用。方法 :以四氯化碳诱导大鼠肝损伤 ,观察桑黄对血清学和组织学指标的影响。结果 :桑黄治疗组大鼠肝细胞变性明显减轻 ,肝组织结构完好 ;血清氨基酸转移酶水平显著降低 ,蛋白合成能力增强 ;血清活性氧显著减少 ,肝组织超氧化物歧化酶活力提高 ;血清白细胞介素 -4水平降低 ,γ -干扰素显著增高。结论 :桑黄具有保护肝细胞功能 ,抗脂质过氧化和调节炎症因子水平为其作用机理。OBJECTIVE:To study the protecting effect of Phellinus igniarius on liver injury.METHODS:Liver injury was induced by carbon tetrachloride in rats.Parameters of serum samples and tissue samples were analyzed to show the effect of Phellinus igniarius on liver injury.RESULTS:Degeneration of hepatocytes was obviously prevented in rats treated with Phellinus igniarius;the liver construction was well maintained.Phellinus igniarius could significantly decrease the serum levels of aminotransferase,active oxygen and IL-4,while increase the serum level of IFN-γand SOD activity in liver tisˉsue.CONCLUSION:Phellinus igniarius can protect hepatocytes from injury through anti-lipid peroxidation and regulating inflammatory factors.

关 键 词：桑黄 四氯化碳 大鼠 肝损伤 保护作用 血清学 组织学 氨基酸转移酶 超氧化物歧化酶 白细胞介素-4 活性氧 真菌 肝硬化 肝腹水 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]