马布特罗对豚鼠的平喘作用研究  

Antiasthmatic Effect of Mabuterol in Guinea Pigs

作　　者：王学娅[1] 赵怀清[2] 王美惠[1] 郭季安[1] 

机构地区：[1]辽宁省基础医学研究所,沈阳市110005 [2]沈阳药科大学药学院,沈阳市110016

出　　处：《中国药房》2003年第5期272-273,共2页China Pharmacy

摘　　要：目的 :研究马布特罗对豚鼠的平喘作用。方法 :分别以2 %氯化乙酰胆碱和0 1 %磷酸组织胺致清醒豚鼠出现严重的呼吸困难。结果 :马布特罗对2 %氯化乙酰胆碱和0 1 %磷酸组织胺混合液所诱发的清醒豚鼠哮喘有明显的抑制作用 ,并显著延长引喘潜伏期 ,减少哮喘诱发抽搐动物数。马布特罗的支气管扩张作用呈剂量依赖关系 ,半数有效量 (ED50)为0 2mg/kg,95%可信限为0 08～0 49mg/kg。结论 :马布特罗的支气管扩张作用较沙丁胺醇有效期长且作用强。OBJECTIVE:To study the antiasthmatic effect of Mabuterol in guinea pigs.METHODS:Severe dyspnea was induced by2%acetylcholine and0.1%histamine solution in conscious guinea pigs.RESULTS:Experiment showed that Mabuterol could significantly inhibit the experimental asthma induced by mixture of2%acetylcholine and0.1%histamine solution in conscious guinea pigs.It also significantly prolonged the latency of induced asthma and decreased the number of guinea pigs on twitches induced by asthma.Bronchodilating effect of Mabuterol was in a dose-dependent manner.The ED 50 of Mabuterol was0.2mg/kg and95%confidence limit was0.08～0.49mg/kg.CONCLUSION:In comparison with salbutanmol,Mabuterol is longer in duration and more potent in action of bronchodilatation.

关 键 词：马布特罗 豚鼠 平喘作用 氯化乙酰胆碱 磷酸组织胺 哮喘 潜伏期 支气管扩张药 Β2-受体激动剂 

分 类 号：R974.3[医药卫生—药品] R969.4[医药卫生—药学]