盐酸乌拉地尔(利喜定)注射液与临床常用5种药物的配伍稳定性考察  

Study on the Stability of Urapidil Injection Mixing With Five Commonly-used Drugs

作　　者：张淑慧[1] 万国华[1] 蔡温儒[1] 马杰[1] 孙颖光[1] 

机构地区：[1]河北省人民医院,石家庄市050051

出　　处：《中国药房》2003年第5期301-302,共2页China Pharmacy

摘　　要：目的 :考察盐酸乌拉地尔注射液分别与氯化钾、门冬氨酸钾镁、碳酸氢钠、维生素C、盐酸利多卡因5种注射液的配伍稳定性。方法 :采用紫外分光光度法考察各配伍液在室温条件下 (15℃～25℃ )配伍0h～8h内吸收度、吸收曲线变化 ,测定 pH值 ,同时观察其外观和普通显微镜下的变化。结果 :盐酸乌拉地尔注射液在10 %葡萄糖输液中分别与以上5种注射液混合配伍后 ,pH值、外观、普通显微镜下及紫外吸收光谱各项检查均无变化。结论 :盐酸乌拉地尔注射液分别与以上5种注射液配伍稳定。OBJECTIVE:To study the stability of Urapidil injection separately mixing with KCl injection,potassium magˉnesium-L-aspartate injection,NaHCO 3 injection,vitamine C injection and lidocaine injection in10%glucose injecˉtion.METHODS:Ultraviolet spectrophotometry was used for detecting the changes of absorbance,absorption curve,and pH at15℃～25℃within0～8hours,and the external appearance and changes under light microscope were observed.RESULTS:There were no evident changes in absorbance,absorption curve,external appearance,microscopic findings and pH.CONCLUSION:Urapidil injection is stable in mixing with above-mentioned5drugs in10%glucose solution.

关 键 词：盐酸乌拉地尔 注射液 利喜定 氯化钾 门冬氨酸钾镁 碳酸氢钠 维生素C 盐酸利多卡因 配伍 稳定性 葡萄糖液 抗高血压药物 

分 类 号：R972.4[医药卫生—药品] R961[医药卫生—药学]