灰毛泡根部的化学成分  

Chemical constituents from root of Rubus irenaeus

作　　者：刘戎[1] 丁立生[1] 陈能煜[2] 王明奎[1] 

机构地区：[1]中国科学院成都生物研究所,四川成都610041 [2]兰州大学化学系,甘肃兰州730000

出　　处：《中草药》2003年第5期394-396,共3页Chinese Traditional and Herbal Drugs

基　　金：四川省青年科技基金会资助

摘　　要：目的　研究灰毛泡根部甲醇提取物的化学成分。方法　用乙酸乙酯萃取 ,正相和反相硅胶 (MCI ,Rp 18)柱色谱分离 ,并通过波谱技术 (13 CNMR ,DEPT ,1HNMR ,FABMS)及标准样品对照鉴定结构。结果　分离鉴定了10个化合物 ,分别为 2α ,19α 二羟基 3 羰基乌索 12 烯 2 8 酸 (Ⅰ )、2 羰基坡曼酸 (Ⅱ )、覆盆子酸 (Ⅲ )、蔷薇酸 (Ⅳ )、2α ,3α ,19α 三羟基齐墩果 12 烯 2 8 酸 (Ⅴ )、2 ,3 O 异丙叉蔷薇酸 (Ⅵ )、坡曼酸 (Ⅶ )、2α ,3β 二羟基羽扇豆烷 2 0 (2 9) 烯 2 8 酸 (Ⅷ )、儿茶素 (Ⅸ )和胡萝卜苷 (Ⅹ )。结论　这是首次报道该植物的化学成分。Object To investigate the chemical constituents from the methanol extract of the root of Rubus irenaeus Focke. Methods EtOAc extraction, normal and reverse phase silica gel column chromatography were used for isolation. Spectroscopic methods ( 13 CNMR , 1HNMR , DEPT, 2DNMR, and FAB-MS) and comparison with authentic samples were used for identification. Results Ten compounds were isoated and characterized as 2α, 19α-dihydroxyl-3-oxo-urs-12-en-28-oic acid (Ⅰ), 2-oxo-pomolic acid (Ⅱ), fupenzic acid (Ⅲ), euscaphic acid (Ⅳ), 2α, 3α, 19α-trihydroxyl-olean-12-en-28-oic acid (Ⅴ), 2, 3-O-isopropylidenyl euscaphic acid (Ⅵ), pomolic acid (Ⅶ), 2α, 3β-dihydroxyl-lup-20(29)-en-28-oic acid(Ⅷ), catechin (Ⅸ) and daucosterol (Ⅹ). Conclusion These compounds were obtained from this plant for the first time.

关 键 词：灰毛泡根部 化学成分 乙酸乙酯萃取 甲醇提取物 波谱技术 

分 类 号：R284.1[医药卫生—中药学]