肾病患者血清载脂蛋白A_1、B、高密度脂蛋白胆固醇水平的测定价值  

Concentrations of apolipoprotein A1、apolipoprotein B and high-density lipoproteins in serum of renal disease patients:a pragmatic approach of probe into

作　　者：杨勇[1] 江琳[1] 彭燕[1] 谭琳琳[1] 任君[1] 刘利[1] 王国富[1] 张国华[1] 

机构地区：[1]解放军324医院,重庆400020

出　　处：《宁夏医学杂志》2003年第5期259-260,共2页Ningxia Medical Journal

摘　　要：目的　为探讨肾病患者继发动脉粥样硬化性心血管合并症的危险因素。方法　用免疫比浊法和直接测定法测定 2 7例无合并症的肾病患者和 36例健康人的血清载脂蛋白 (apo)A1、B、高密度脂蛋白胆固醇 (HDL -c)水平。结果　对照组的apoA1、apoB、apoA1/apoB ,HDL -c水平分别为 1.4 8± 0 .2 8g/L、0 .93± 0 .2 0 g/L、1.37±0 .34、1.4 8± 0 .30mmol/L ;患者分别为 1.2 1± 0 .31g/L、1.34± 0 .2 2g/L、0 .78± 0 .4 0、0 .98± 0 .36mmol/L ,两组间的结果差异均具有显著性意义 (P <0 .0 5 )。结论　肾病患者在出现动脉粥样硬化性心血管合并症之前 ,体内已经具备了诱发合并症的生化基础 ,故临床上应早期采取针对性预防措施。Objectives To discuss the potential risk of atherosclerotic cardiac disease which may complicate and form of renal disease.Methods We measured apolipoprotein A1(apoA 1),apolipoprotein B(apoB) and higdensity lipoprotei(HDL-C) With a behring nephelometor using monoclonal antisera and an enzyme end.the serum contrations of risk factors in 27 renal disease patients without merging atherosclerotic cardiacdisease and 36 controls in good health measured.Results The apoA 1,apoB,HDL-C and apoA 1/apoB in the controls were 1.48±0.28g/L,0.93±0.20g/L,1.37±0.34 and 1.48±0.30mmol/L respectively;and those in the patient were 1.21±0.31g/L,1.34±0.22g/L,0.78±0.40 and 0.98±0.36mmol/L respectively(P<0.05).Conclusions Sevrl studies have shoun that apoA 1,apoB apoA 1/apoB and HDL-C are significant predictors of atherosclerotic cardiac disease.Unfortunately,these risk factors are present we suggest that in patients with renal disease.We suggest that a therosclerotic cardiac disease should be prevented early during the clinical treatment of renal disease.

关 键 词：肾病 血清 载脂蛋白A1 载脂蛋白B、高密度脂蛋白 危险因素 冠心病 

分 类 号：R446.6[医药卫生—诊断学]