艾滋病病毒感染者/艾滋病病人临床实验室检测方法研究  

Study on clinical laboratory tests for HIV/AIDS patients

作　　者：姜拥军[1] 王亚男[1] 张子宁[1] 刘静[1] 张旻[1] 韩晓旭[1] 周立平[1] 文小宁[1] 刘瑛[1] 叶小卉[1] 尚红[1] 

机构地区：[1]中国医科大学附属第一医院艾滋病研究室,沈阳110001

出　　处：《中华检验医学杂志》2003年第3期139-141,共3页Chinese Journal of Laboratory Medicine

基　　金：国家"十五"科技攻关课题资助 ( 2 0 0 1BA70 5B0 1)

摘　　要：目的　研究艾滋病病毒感染者 /艾滋病病人 (HIV/AIDS)临床实验室检测指标的意义。方法　应用临床实验室检测方法对病毒载量、T淋巴细胞、免疫球蛋白、β2 微球蛋白、淀粉酶等指标进行检测。结果　HIV/AIDS患者CD4+T细胞数量、CD4/CD8比值与HIV抗体阴性对照相比明显减低(P <0 0 0 1;P <0 0 0 1)HIV慢性感染者CD8+T细胞与HIV抗体阴性对照及AIDS病人相比明显升高(P <0 0 0 1;P <0 0 0 1;)HIV/AIDS患者的CD4+T淋巴细胞绝对数量与CD4百分比 (r =0 789,P <0 0 0 1)及CD4/CD8比值 (r=0 777,P <0 0 0 1)呈明显正相关 ;HIV/AIDS患者 β2 微球蛋白高于HIV抗体阴性对照 (P <0 0 0 1)。HIV/AIDS患者肝功能、肾功能、血糖、血脂、血淀粉酶与HIV抗体阴性对照相比差异无明显意义 (P >0 0 5 )。结论　T淋巴细胞、病毒载量、β2 微球蛋白等指标的检测对判定HIV/AIDS患者疾病程度、预后及治疗效果具有重要意义。Objective To study the value of clinic laboratory tests in human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome(AIDS) patients.Methods Viral load, T lymphocytes, immunoglobulins, β 2 microglobulin, blood glucose, blood lipid,amylase, liver function, renal function, blood routine test and urine routine test were determined with clinical laboratory methods.Results The CD4 absolute count and ratio of CD4/CD 8 in HIV/AIDS were significantly decreased compared with that of HIV negative controls ( P<0.001; P<0.001); The CD8+ T lymphocytes in HIV chronic infection was significantly higher than that of HIV negative controls (11 P<0.001;significantly decreased compared with that of HIV negative controls ( P<0.001; P<0.001); The CD8+ T lymphocytes in HIV chronic infection was significantly higher than that of HIV negative controls ( P<0.001; P<0.001); the CD4+ T lymphocytes in HIV/AIDS patients is positively related to the CD4 percentage(r=0.789, P<0.001) and ratio of CD4 to CD8(r=0.777, P<0.001); the level of β 2 microglobulin in HIV/AIDS was much higher than the controls. Conclusion The tests of T lymphocytes, viral load and β 2 microglobulin play an important role in evaluation of disease progression, prognosis and efficiency of treatment in HIV/AIDS patients.

关 键 词：艾滋病病毒感染 艾滋病 临床实验室检测 方法研究 

分 类 号：R446.6[医药卫生—诊断学] R446.5[医药卫生—临床医学] R446