铃蟾肽、P物质受体脱敏对迟慢兴奋性突触后电位的影响  

The effect of seperate desensitization of substance P and bombesin receptor on ls-EPSP in neurons of guinea pig inferior mesenteric ganglion

作　　者：柯道平[1] 孔德虎[1] 王刚[1] 祝延[1] 黄振信[1] 

机构地区：[1]安徽医科大学生理学教研室神经生理实验室,安徽合肥230032

出　　处：《蚌埠医学院学报》2003年第3期201-202,F003,共3页Journal of Bengbu Medical College

基　　金：安徽省教育厅自然科学研究资助项目 (99JL0 119)

摘　　要：目的 :探讨豚鼠肠系膜下神经节 (IMG)细胞铃蟾肽 (bombesin ,Bom)、P物质 (substanceP ,SP)受体间相互作用及对迟慢兴奋性突触后电位 (ls EPSP)的影响。方法 :离体细胞内记录 ,并观察细胞的去极化、ls EPSP的时程、幅度。结果 :SP受体脱敏可使SP敏感细胞的ls EPSP阻抑 ,但对Bom去极化无影响 ;Bom受体脱敏可使Bom敏感细胞的ls EPSP阻抑 ,但对SP受体去极化无影响。结论 :Bom、SP可通过各自的突触后膜受体形成ls EPSP ,无交互脱敏现象。Objective:To investigate the effects of desensitization of substance P and bombesin(Bom) receptor on ls EPSP in neurons of guinea pig inferior mesenteric ganglion.Methods:Intracellular recordings were made from neurons of the isolated guinea pig IMG.Results:SP receptor desensitization can abolish or markedly attenuate ls EPSP in SP sensitive neurons,but had not any effects on Bom mediated depolarization;By contrast,Bom receptor desensitization can also abolish or markedly attenuate ls EPSP in Bom sensitive neurons,but had no effect on SP mediated depolarization.Conclusions:Bom and substance P can produce ls EPSP via respective receptor on the membrane of synapse,and no cross desensitization between receptors. [

关 键 词：铃蟾肽 P物质 受体脱敏 迟慢兴奋性突触后电位 神经节 生理学 

分 类 号：R338[医药卫生—人体生理学]