糖尿病患者血浆凝血酶-抗凝血酶和D-二聚体检测  

Determination of thrombin-antithrombin complex and D-dimer in diabetes mellitus patients

作　　者：张燕[1] 李卓江[1] 景本年[1] 房桂菊[1] 董群荣[1] 

机构地区：[1]贵阳医学院附属医院血液内科,贵州贵阳550004

出　　处：《临床荟萃》2003年第10期561-562,共2页Clinical Focus

摘　　要：目的　探讨糖尿病患者血浆凝血酶抗凝血酶复合物 (TAT)、D 二聚体 (D D)水平的临床意义。方法　选取 2型糖尿病患者 4 0例 ,分为微血管病变组 2 4例及单纯糖尿病组 16例 ;正常对照组 30例。采用酶联免疫吸附试验 (ELISA)测定血浆TAT和D D水平。结果　糖尿病组、正常对照组血浆TAT和D D水平分别为 (14 .95± 6 .5 4 )μg/L、(1.5 6± 0 .72 )mg/L ;(2 .6 5± 1.2 2 ) μg/L、(0 .19± 0 .0 8)mg/L ,两组相比差异有统计学意义。糖尿病微血管病变组较单纯糖尿病组及正常对照组TAT、D D含量均明显增高 (前两者TAT分别为 (2 1.34± 8.91) μg/L、(9.6 7±2 .72 ) μg/L ;D D分别为 (2 .95± 0 .84 )mg/L、(0 .2 8± 0 .0 9)mg/L ,而单纯糖尿病组较正常对照组仅TAT增高差异有统计学意义 ,D D未见明显增高。结论　糖尿病患者体内存在凝血及纤溶的变化 ,血浆TAT及DObjective To study the plasma levels of thrombin antithrombin complex(TAT) and D dimer(D D) in diabetes mellitus(DM) for elucidating their clinical significance.Methods The plasma levels of TAT and D D were determined by ELISA in 40 cases of type 2 diabetes mellitus(DM) patients with or without microangiopathy and 30 normal subjects.Results The plasma levels of TAT and D D were ( 14.95 ± 6.54 ) μg/L,( 1.56 ± 0.72 ) mg/L;( 2.65 ± 1.22 ) μg/L,( 0.19 ± 0.08 ) mg/L in DM group and normal control group,respectively.The DM group had higher TAT and D D levels than normal group,while DM patients with microangiopathy were higher than those without this complication,no significant D D levels were proved between DM group without microangiopathy and normal group.Conclusion DM patients have abnormal balance of coagulation and fibrinolysis.The determination of TAT and D D is useful for the early diagnosis and therapy.

关 键 词：糖尿病 非胰岛素依赖型 凝血酶-抗凝血酶复合物 D-二聚体 血浆 

分 类 号：R587.1[医药卫生—内分泌]