端侧神经吻合后供神经节内cAMP含量和超微结构变化  

cAMP level and ultrastructure's variation of donor nerve ganglion after end-to-side neurorrhaphy

作　　者：陈绍宗[1] 曹祖峰[1] 程飚[1] 

机构地区：[1]第四军医大学唐都医院整形烧伤科,陕西西安710038

出　　处：《第四军医大学学报》2003年第9期861-862,共2页Journal of the Fourth Military Medical University

摘　　要：AIM: To study the relations of cAMP level and ultrastructure’s variation to initiation of axon regeneration in donor nerve ganglion after end to side neurorrhaphy. METHODS: The two Greater Auricular Nerve of Rabbits were anastomosed by end to side neurorrhaphy. The nerve on the left side was designated as Donor nerve, and the right one, the receptive nerve. At various postoperative time, the sumple of donor nerve ganglion C2 was taken to make camp assaying and observe the ultrastructure’s variation using transmitted electron microscope. RESULTS: In normal C2 ganglion, the cAMP level was (1.62±0.12) μmol·kg -1 . In donor nerve C2 ganglion, the cAMP level was lower than normal in early time(2 days), but it rosed rapidly in 4 days, and reachedclimax in 7 days after operation. Then it fell gradually and restored basically to normal in 60 days, so the ultrastructure did. CONCLUSION: cAMP level and ultrsastructure of donor nerve ganglion have changed immediately after end to side Neurorrhaphy. cAMP was a signal of axon regeneration and the ultrastructre’s variation was a reversible course. They are closely correlated with axon regeneration.AIM: To study the relations of cAMP level and ultrastructure's variation to initiation of axon regeneration in donor nerve ganglion after end to side neurorrhaphy. METHODS: The two Greater Auricular Nerve of Rabbits were anastomosed by end to side neurorrhaphy. The nerve on the left side was designated as Donor nerve, and the right one, the receptive nerve. At various postoperative time, the sumple of donor nerve ganglion C2 was taken to make camp assaying and observe the ultrastructure's variation using transmitted electron microscope. RESULTS: In normal C2 ganglion, the cAMP level was (1.62±0.12) μmol·kg -1 . In donor nerve C2 ganglion, the cAMP level was lower than normal in early time(2 days), but it rosed rapidly in 4 days, and reachedclimax in 7 days after operation. Then it fell gradually and restored basically to normal in 60 days, so the ultrastructure did. CONCLUSION: cAMP level and ultrsastructure of donor nerve ganglion have changed immediately after end to side Neurorrhaphy. cAMP was a signal of axon regeneration and the ultrastructre's variation was a reversible course. They are closely correlated with axon regeneration.

关 键 词：端侧神经吻合 供神经 神经节 环磷酸腺苷 超微结构 

分 类 号：R622[医药卫生—整形外科]