1-(2-羟基-5-甲基苯基)苯乙胺的合成  

Synthesis of 1-(2-Hydroxy-5-methylphenyl)phenethylamine

作　　者：吴加胜[1] 张妍[1] 张广友[1] 

机构地区：[1]济南大学化学工程学院,山东济南250022

出　　处：《山东化工》2003年第2期1-3,11,共4页Shandong Chemical Industry

基　　金：山东省自然科学基金资助项目 (编号 :Y2 0 0 2B0 5 )

摘　　要：对甲基苯酚与苯乙酰氯酯化得到苯乙酸 ( 4 -甲基 )苯酯 ;然后在三氯化铝作用下重排得到苄基 ( 2 -羟基 -5 -甲基 )苯基酮 ;此酮经硫酸二甲酯甲基化得到苄基 ( 2 -甲氧基 -5 -甲基 )苯基酮 ,再和甲酸铵反应得到 1-( 2 -甲氧基 -5 -甲基苯基 )苯乙胺 ,最后经氢溴酸水解得到 1-( 2 -羟基 -5 -甲基苯基 )苯乙胺。所有中间体和最终产品的结构均由IR、元素分析、1 HNMR得到证实。In this paper, p-tolyl phenylacetate was prepared from the reaction of 4-methylphenol and phenylacetyl chloride. 2-Hydroxy-5-methylphenyl benzyl actone was obstained through a rearrangement reaction using AlCl 3 as catalyst. Then hydroxy was methylated by Me 2SO 4 under PTC conditions. Then 2-methoxy-5-methylphenyl benzyl actone was aminated by HCO 2NH 4, and 1-(2-methoxy-5-methylphenyl)phenethylamine was obstained. At last, 1-(2-hydroxy-5-methylphenyl)phenethylamine was obstained by hydrosis reaction using hydrobromide. The structures of intermediate were confirmed by IR,element analysis and 1HNMR spectra.

关 键 词：l-(2-羟基-5-甲基苯基)苯乙胺 合成 对甲基苯酚 苯乙酰氯 酸化 苯乙酸(4-甲基)苯酸 

分 类 号：TQ246.31[化学工程—有机化工]