氨苄西林钠中丙酮、异丙醇含量测定  

Test for Residue Solvent Content in Ampicillin Sodium Raw Material

作　　者：崔振辉[1] 张红梅[1] 马晓燕 

机构地区：[1]哈药集团制药总厂,150086 [2]哈医大第一附属医院

出　　处：《黑龙江医药》2003年第3期165-166,共2页Heilongjiang Medicine journal

摘　　要：目的:建立一种气相色谱法测定原料药氨苄西林钠中丙酮、并丙醇二有机溶剂残留量。方法:选正丙醇作内标物,在极性弹性石英毛细柱上进行各组分分离,效果良好。柱温:85n℃;进样口温度:200℃;检测器温度:250℃;结果平均回收率:丙酮100.1％、异丙醇100.0％;结论该方法克服了进样量不准确的缺点,重现性好,精度高。Determine the content of acetone and isopropanol in ampicillin sodium raw materi- al with the method of gas chromatography method choose n-propanol as the internal standard,and separate each component on a polar elastic quartz capillary column.The effect is well.The oven temperature was set at 85℃,with injector at 200℃ and FID temperature at 250℃,the average re- covery was at 100.1％ and 100.0％ for acetone and isopropanol.The results showed that the method is the characters of reproducibility and precision.

关 键 词：氨苄西林钠 丙酮 异丙醇 含量 测定 内标物 

分 类 号：R927.2[医药卫生—药学]