Y染色体单倍型在贵州苗族人群中的多态性分布  

The Polymorphism Distribution of Y - chromosome Haplotypes in A Miao Population of Guizhou

作　　者：李永念[1] 左丽[1] 文波[1] 黄微 金力[2,3] 

机构地区：[1]贵阳医学院免疫学教研室 [2]国家人类基因组南方研究中心 [3]复旦大学遗传所上海 200433

出　　处：《贵阳医学院学报》2003年第2期98-100,105,共4页Journal of Guiyang Medical College

基　　金：国家自然科学基金(39896200)

摘　　要：目的:调查Y染色体单倍型在贵州省苗族人群中的分布,从父系历史探寻贵州省苗族人的起源和迁移及其与其他民族间的亲缘关系。方法:采用PCR-RFLP法观察了由13个单核苷酸多态位点(SNPs)组成的Y染色体单倍型在贵州省苗族人群中的多态性分布,并将结果与我国其他民族及世界各大洲人群进行比较。结果:贵州省苗族人群中具有我国南方人群特异性的H7、H11和H12单倍型出现,其单倍型分布与我国南方汉族、土家族、彝族、布依族等较为接近,尤以M122(H5+H6)的频率较高。结论:提示贵州省苗族人属于我国南方群体,与南方汉族人及土家族、彝族人有一定的亲缘关系。Objective: To investigate the polymorphism distribution of Y-chromosome haplotypes in Miao population. Methods: PCR-RFLP was used to detect the frequency of Y - chromosome haplotypes consisted of thirteen single nucleotide polymorphism alleles in Miao people. Results: Nine Y -chromosome haplotypes (H1, H2, H5, H6, H7, H8, H9, H11, H1 2) were found in the samples. The frequency distribution of these haplotypes in Miao people were very similar to that in other southern populations in China, including Han, Tujia, and Yi people. Conclusion: It indicates that there is a closer genetic relationship among southern Han, Tujia, and Yi populations implicating a common ancestry.

关 键 词：Y染色体单倍型 贵州 苗族人群 多态性 

分 类 号：Q987.1[生物学—遗传学]