兔胸腹部爆炸伤后的血液浓缩及其可能机制  

The Blood Concentration After Explosive Injury on the Chest-abdomen of Rabbits and Its Possible Mechanism

作　　者：陈志强[1] 王建民[1] 李兵仓[1] 张良潮[1] 许川[1] 

机构地区：[1]中国人民解放军第三军医大学大坪医院野战外科研究所,邮政编码重庆400042

出　　处：《微循环学杂志》2003年第2期1-3,共3页Chinese Journal of Microcirculation

基　　金：中国人民解放军军队"十五"指令性课题 (0 1L0 60 )

摘　　要：目的 :探讨爆炸性冲击伤后血液浓缩的特点及其可能的机制。方法 :采用雷管所致兔爆炸性冲击损伤模型 ,以1 2 5I 白蛋白标记的方法 ,观察爆炸性冲击伤前后红细胞压积与血浆外渗情况。结果 :距爆源 2 0cm处的爆炸冲击波作用时 ,红细胞压积增加 14 .9% ,血浆丢失为对照的 5 .12倍 ,白蛋白漏出率为伤前的 1.3倍 ,左肺组织中残留放射性较对照组增加约 18% ,该点平均压力峰值为 174 .4kPa。结论 :爆炸冲击伤后的红细胞压积增加。Objective: To explore the characteristics of blood concentration and its possible mechanism after explosive blast injury. Method: The model of explosive blast wounded on rabbits and the 125 I albumin dilution method have been used. Results: The explosive blast far from 20 cm can cause that hematocrit increased 14.9%, the loss of plasma is 5.12 fold compared with control group, the rate of 125 I albumin escaped is 1.3 fold compared with control group, the remained radiation in left lung tissue increased approximately 18%. On this site, average peak pressure of blast is 174.4 kPa. Conclusion: The explosive blast can cause hematocrit increase, plasma loss, albumin escaped from circulation, which may be important reason of microcirculation dysfunction after blast injury.

关 键 词：兔 胸腹部 爆炸伤 血液浓缩 大白兔 血容量 红细胞容量 血浆容量 

分 类 号：R826.5[医药卫生—临床医学]