萃取法氯化血红素脱铁的初步研究  

Primary Investigation on the Extraction of Hemin Using An Ultrasonic Method

作　　者：刘振荣[1] 徐锐[1] 王君[1] 陈红亮[1] 贾卫国[1] 

机构地区：[1]辽宁大学化学系,辽宁沈阳110036

出　　处：《辽宁大学学报（自然科学版）》2003年第2期150-154,共5页Journal of Liaoning University：Natural Sciences Edition

摘　　要：详细报导了一种氯化血红素脱铁的TBP萃取新方法,在萃取时间1h,萃取剂TBP加入量为Fe量的10～20倍,盐酸加入量为硫酸体积的1/3,稀释剂选用非极性的苯和萃取温度40℃等条件下,氯化血红素的脱铁率和血卟啉及血卟啉衍生物的纯度分别达到了99.82%和97.85%。采用此方法不但降低了生产成本,而且还缩短了生产周期。In this paper, the new extraction method to measure the deironation from hemin using TBP (tributyl phosphate) as extraction agent was reported in details. The proporatin of deironation and the purity of hematoporphyrin or hematoporphyrin derivative achieved 99.82 % and 97 .85 % , respectively, under the conditions of an-hour extraction TBP/Fe =10-20, hydrochloric acid/sulfuric acid 1/3 (in volume), non-polar benzene as diluent agent and 40C extraction temperature etc. This method adopted can not only reduce the production cost but also shorten the procedure time.

关 键 词：氯化血红素 脱铁 萃取法 萃取时间 萃取剂 萃取温度 血卟啉 增敏剂 肿瘤治疗 

分 类 号：R979.1[医药卫生—药品] TQ460.6[医药卫生—药学]