益肾Ⅰ方对阿霉素诱导大鼠肾病综合征的治疗作用  

Efficacy of Yishen formula in treatment of adriamycin induced nephritic syndrome(NS) in rats

作　　者：谭海荣 刘恩棋[2] 潘竞锵 肖柳英 韩超 林洁茹[2] 郑琳颖[2] 李博萍[2] 关庆丽[3] 陈文慧[3] 

机构地区：[1]广州市中医中药研究所,广州510130 [2]广州市中医医院,广州510130 [3]广东药学院药学系,毕业实习生广州510224

出　　处：《中国新药杂志》2003年第4期264-267,共4页Chinese Journal of New Drugs

基　　金：广州市重点资助项目 [(JB0 2 ) 97-Z -4 6-0 1]

摘　　要：目的 :探讨益肾Ⅰ方水提取物和六味地黄胶囊对阿霉素 (ADM)致大鼠肾病综合征的作用。方法 :以ipADM 3mg·kg-1·d-1,q3d× 3d诱导大鼠肾病综合征模型 ,观察益肾Ⅰ方高和低剂量组及六味地黄对病鼠肾功能、血脂、血浆蛋白、肾组织病理学和抗氧化作用的影响。结果 :与模型对照组比较 ,益肾Ⅰ方 2个剂量和六味地黄胶囊均能降低病鼠高值尿素氮和肌酐水平及总胆固醇、三酰甘油和丙二醛含量 (P <0 .0 1) ,提高病鼠低下的总蛋白和白蛋白含量 (P <0 .0 1) ,增强超氧化物岐化酶活性 (P <0 .0 1) ;改善病鼠肾组织病理学的改变 (P <0 .0 1) ,但六味地黄对病鼠肾组织病理学的改变 ,则差异未见显著性 (P >0 .0 5 )。在上述各观察指标中 ,各药间的作用强度差异也未见显著性 (P >0 .0 5 )。结论 :益肾Ⅰ方和六味地黄胶囊均具有对抗阿霉素性大鼠肾病综合征的氮质血症、低蛋白血症和高脂血症作用。Objective:To study the efficacy of water extract of Yishen formula(YSF) and Liuweidihuang(LWDH) capsule in treatment of NS rats induced by adriamycin(ADM).Methods:NS rat model was created by intra peritoneal administration of ADM.NS rats were divided into 4 groups:high dose YSF group,low dose YSF group,LWDH group and control group.Renal function,blood lipids,plasma protein,renal cell histological pathology and anti oxidation effect were observed.Results:In active groups,the TC(total cholesterols),BUN(blood urea nitrogen),creatinine,TG(triglyceride),and albumin were significantly decreased( P <0.01),the TP(total proteins) and MDA(malondialdehyde) were significantly decreased( P <0.01);the superoxide dismutase (SOD) activity was enhanced,and the renal cell histological pathology was improved( P <0.01) but no significant difference in renal cell histological pathology was observed in LWDH group( P >0.05).The parameters mentioned above were not observed significant difference in different dose groups.Conclusion:Both the YSF and LWDH are effective in treatment of hypermitrogenemia,hypoproteinemias,and hyperlipemia in NS rats induced by ADM.

关 键 词：益肾Ⅰ方 六味地黄胶囊 阿霉素 肾病综合征 大鼠 

分 类 号：R282.71[医药卫生—中药学]