通脉冲剂治疗动脉粥样硬化闭塞症的实验研究  

Experimental Study on Treatment of Atherosclerosis Obliterans with Tongmai Decoction

作　　者：刘健[1] 齐清会[1] 

机构地区：[1]天津医科大学总医院中西医结合外科,300052

出　　处：《天津医药》2003年第5期304-306,F002,共4页Tianjin Medical Journal

摘　　要：目的 :探讨由七叶一枝花、银杏叶、丹参、元参、川芎和甘草制成的通脉冲剂治疗动脉粥样硬化闭塞症(ASO)的疗效及作用机理。方法 :健康大耳白家兔30只 ,综合利用高脂、高胆固醇饲料喂养、气囊导管机械性损伤动脉内膜及免疫性损伤等方法制作ASO动物模型。制模后随机分为模型组、治疗组和对照组 ,每组10只。以模型组验证模型 ,并与正常组(10只)进行对比 ;制模成功后治疗组给予通脉冲剂治疗 ,对照组除不给通脉冲剂外 ,其他同治疗组 ,共14周。于实验结束后取髂股动脉做病理检查 ,并观察血甘油三酯(TG)、总胆固醇(TC)、血浆内皮素(ET)和一氧化氮(NO)水平的变化。结果 :治疗组动物服用通脉冲剂14周后 ,跛行情况明显改善 ,血甘油三脂、总胆固醇、血浆ET逐渐降低 ,血浆NO逐渐上升 ,与对照组比较有显著性差异(P<0 .01)。病理检查结果显示动脉内膜病变及斑块形成均较对照组有明显改善。结论Objective:To experimentally study the treatment of atherosclerosis obliterans(ASO)with Tongmai Decoction.Methods:Thirty rabbit models with ASO were randomly divided into model group(n=10),treatment group(n=10)and control group(n=10).The treatment group was treated with Tongmai Decoction for14weeks while the control group was given a normal fodder without any treatment.The pathological exˉamination of iliofemoral artery was made at the end of experiment.The changes of symptom were observed and the levels of total cholesterol(TC),triglyceride(TG),endothelin(ET)and nitric oxide(NO)were determined successively during the process.Results:After14weeks of treatment with Tongmai Decoction,the claudications and the pathologic manifestations of ASO animal were improved.The levels of TC,TG and ET decreased obviˉously while the level of NO increased gradually in the treatment group(P<0.01).Conclusion:Tongmai Decocˉtion has a good effect on rabbit ASO models.

关 键 词：动脉粥样硬化闭塞症 通脉冲剂 治疗 实验研究 中医药疗法 

分 类 号：R259.435[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]