萘普生的化学除氧-流体室温燐光法研究  

Study on Naproxenum by Chemical Deoxygenation Liquid Room Temperature Phosphorimetry

作　　者：徐文祥[1] 魏玉霞[1] 董川[1] 晋卫军[1] 

机构地区：[1]山西大学化学化工学院,山西太原030006

出　　处：《山西大学学报（自然科学版）》2003年第2期159-162,共4页Journal of Shanxi University(Natural Science Edition)

基　　金：国家自然科学基金 ( 2 0 2 75 0 2 2 );山西省自然科学基金 ( 2 0 0 110 10 )

摘　　要：利用化学除氧 -微乳状液增稳室温光法 ( ME- RTP)对萘普生进行了研究 ,比较了萘普生在微乳状液体系和胶束体系中的室温光特性及其影响因素 .建立了测定萘普生的室温光新方法 .结果表明 ,在外重原子( TINO3)诱导下 ,萘普生在微乳状液体系和胶束体系中分别于 5 10 nm和 5 12 nm处有较强的室温光发射 ;相同实验条件下 ,萘普生在微乳状液体系中的 RTP强度比在胶束体系中大 ,且实验条件较宽容 ;在微乳状液体系和胶束体系中 ,萘普生的线性范围分别为 2× 10 - 5mol/L～ 5× 10 - 4 mol/L 和 5× 10 - 6 m ol/L～ 7× 10 - 5mol/L,检出限分别为 2 .1× 10 - 6 mol/L 和 1.9× 10 - 6 mol/L.Naproxenum was studied by using chemical deoxygenation liquid room temperature phosphorimetry.Moreover,microemulsion stabilized and micelle stabilized RTP of naproxenum were studied,and the various experimental conditions of determination of naproxenum are discussed.The microenulsion stabilized analytical method of naproxenum were founded.The results show that the heavy atom perturber (T1NO 3)can induce the emission of RTP of naproxenum,and its wavelengths in microemulsion stabilized and micelle stabilized systems are 510 nm and 512 nm,respectively.Under the same conditions,the RTP intensity of naproxenum in microemulsion system is stronger than that in micelle system,and the range of appropriate conditions of ME-RTP is wider than that of MS-RTP.Under the optimum conditions,in microemulsion stabilized and micelle stabilized systems,the linear dynamic ranges are 2×10 -5 mol/L～5×10 -4 mol/L and 5×10 -6 mol/L～7×10 -5 mol/L, and the limit of detection are 2.1×10 -6 mol/L and 1.9×10 -6 mol/L,respectively.

关 键 词：萘普生 化学除氧-流体室温燐光法 微乳状液体系 胶束体系 消炎镇痛药物 

分 类 号：R971.1[医药卫生—药品] R927.2[医药卫生—药学]