次声作用对小鼠视觉电生理学的影响  

Effects of Infrasound on Visual Electrophysiology in Mice.

作　　者：石力[1] 张作明[1] 陈景藻[2] 刘静[2] 

机构地区：[1]第四军医大学航空航天医学系航空临床教研室,陕西西安710033 [2]西京医院理疗科,陕西西安710033

出　　处：《航天医学与医学工程》2003年第2期115-119,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金 (3990 0 162 );军队指令性课题(0 1L0 71)资助

摘　　要：目的探讨次声暴露对小鼠视觉电生理学的影响。方法 1 5 0只昆明种成年雄性小鼠按次声的不同参数随机分为 5大组 ,每组 3 0只 ,每大组小鼠按暴露时间随机分为 6小组 ,每组 5只 ,分别暴露于 8Hz、90dB ,8Hz、1 3 0dB ,1 6Hz、90dB ,1 6Hz、1 3 0dB的次声压力舱中 ,每天暴露 2h ,分别在暴露 0、1、4、7、1 4、2 1d后进行视网膜电图 (ERG)、闪光视诱发电位 (FVEP)、振荡电位 (OPs)的检测。结果 8Hz、90dB ,1 6Hz、90dB实验组视觉电生理指标改变较为相似 ,仅在一些时间点发生改变。 8Hz、1 3 0dB实验组大部分视觉电生理指标在第 7天实验后就明显改变 ,并随着暴露时间的增加而加重。 1 6Hz、1 3 0dB实验组大部分视觉电生理指标在第 1天即明显改变 ,此后增加暴露时间视觉电生理指标有所恢复。结论次声对小鼠视觉电生理功能的影响与次声的强度和频率有关。不同参数次声对小鼠视觉功能影响程度不同 ,可能是由于不同频率的次声与视网膜自身频率接近或符合的程度不同 ,使视网膜不同种类细胞受损程度不一 ,产生不同的电位变化。Objective To investigate the possible effects of infrasound on visual functions. Method One hundred and fifty mature male Kunming mice were divided into 5 groups, in which one was control and the other four were exposed to infrasound of 8 Hz,90 dB;8 Hz,130 dB;16 Hz,90 dB and 16 Hz,130 dB 2 h/d respectively.The exposure time for them were 0,1,4,7,14 and 21 d respectively ,each group was divided into 6 subgroups. Electroretinogram(ERG),oscillatory potentials(OPs), and visual evoked potential(VEP)were recorded after exposure. Result The visual electrophysiological indices after 8 Hz,90 dB and 16 Hz,90 dB exposures were similar except for a little difference at some temporal points(P<0.05). Most of the indices in 8 Hz,130 dB group changed after 7 d exposure, and the longer the exposure ,the more obvious changes were observed(P<0.01). The indices in 16 Hz,130 dB group changed obviously after 1 d and reversed with increase of exposure time(P<0.01).Conclusion The effect of infrasound on visual functions are related to its frequency and intensity. Infrasound of different frequencies causes different levels of retinal resonance, which leads to different degrees of cellular lesion and produces different electrical potentials.

关 键 词：次声 视觉电生理学 视网膜电图 视觉诱发电位 振荡电位 

分 类 号：R852.24[医药卫生—航空、航天与航海医学] R339.14[医药卫生—临床医学]