激光对皮肤层状组织作用的非傅立叶效应及光致热损伤分析  

Analysis of Non Fourier Effect and Laser induced Thermal Damage of Laser irradiated Layered Human Skin Tissue

作　　者：马宁[1] 江世臣[1] 李和杰[1] 张学学[1] 

机构地区：[1]清华大学热能工程系工程热物理所,北京100084

出　　处：《航天医学与医学工程》2003年第2期133-137,共5页Space Medicine & Medical Engineering

基　　金：清华大学机械工程院基础研究基金及实验室设备处开放基金资助

摘　　要：目的分析非Fourier效应对激光与人体皮肤组织相互作用的影响 ,在此基础上研究皮肤病激光灼伤疗法中的光致热损伤。方法采用MonteCarlo方法模拟皮肤组织内的光子传播 ,将激光能量看作组织内热源 ,采用生物传热热波模型 (TWMBT)研究具有不同物理性质的皮肤层状组织中的瞬态温升过程、温度分布和皮肤的热损伤时间 ,由此探讨皮肤病灼伤治疗的时间阈值。结果研究表明 ,由于非Fourier效应的存在 ,皮肤组织各处的温升速率较低 ,需要经过较长的时间才能达到温度峰值 ,因此 ,非Fourier效应对预测皮肤组织的损伤时间阈值有着较大影响。结论关于激光与皮肤层状组织相互作用时的非Fourier效应的理论分析及相应的数值求解对准确预测皮肤组织内的热效应。Objective To analyze the non Fourier effect in layered human skin irradiated by laser beam, and to study the laser induced thermal damage of the human skin. Method Photon transportation in the skin tissue was simulated with the Monte Carlo method. With the laser energy regarded as the internal heat source, transient temperature rising, temperature distribution and thermal damage periods in the layered human skin were analyzed with the thermal wave model of bio heat transfer (TWMBT). The therapeutic period of dermopathy was then discussed in detail. Result Due to the non Fourier effect, temperature rising rates in different depths of skin were comparatively low and a longer period was required to reach the temperature peak value. Therefore, the non Fourier effect was significant for predicting thermal damage time of human skin. Conclusion Theoretical analysis of the non Fourier effect in layered human skin irradiated by laser beam and corresponding numerical solution provide an active guidance for precisely predicting the thermal effect in human skin tissue, controlling the proper therapeutic time of dermatosis, and optimizing laser surgery parameters in dermatotherapy.

关 键 词：皮肤病 激光灼伤疗法 非傅立叶效应 光致热损伤 生物传热热波模型 生物传热 MONTE-CARLO模拟 皮肤组织 

分 类 号：R751[医药卫生—皮肤病学与性病学] R454.2[医药卫生—临床医学]