21d-6°头低位卧床期间运动训练对骨丢失的防护效应  

Preventive Effects of Exercise Training on Bone Loss during 21d-6°Head down Bed rest.

作　　者：刘玉盛[1] 黄伟芬[1] 李丽萍[2] 仲崇发[1] 董荣菂[3] 孙洪义[1] 

机构地区：[1]航天医学工程研究所,北京100094 [2]中国人民解放军306医院,北京100101 [3]北京体育大学,北京100084

出　　处：《航天医学与医学工程》2003年第2期96-99,共4页Space Medicine & Medical Engineering

基　　金：中国载人航天工程资助项目

摘　　要：目的观察 2 1d - 6°头低位卧床运动训练对骨质丢失的防护作用。方法 1 0名男性青年志愿者分为卧床对照组和卧床训练组 ,每组 5人 ,卧床期间训练组每天进行 1h的仰卧位功率自行车训练。分别于卧床前和卧床 2 0d进行了股骨骨密度 (BMD)、血清骨钙素 (BGP)、羟脯氨酸 /肌酐 (HOP/Cr)等指标的测量。结果与卧床前相比 ,对照组平均股骨BMD下降了 5 .8%,而训练组下降 0 .9%,对照组HOP/Cr不仅显著增加而且也显著高于训练组 ,BGP两组均降低 ,但是没有显著性差异。结论 2 1d - 6°头低位卧床运动训练对于骨质丢失具有比较明显的防护效应。Objective To observe the protective effects of exercise training during 21 d -6° head down bed rest(HDBR) on bone loss. Method Ten healthy young men were randomly divided into HDBR group and HDBR exercise group, with 5 in each group. Both groups were exposed to -6° head down bed rest for 21 d. The subjects in the exercise group performed exercise with a bicycle ergometer in supine position 1 h/d during bed rest. Femur bone mineral density (BMD), serum bone gla protein (BGP) as well as hydroxyproline/creatinine (HOP/Cr) were determined before and during 20 d HDBR. Result As compared with the before HDBR values,average femur BMD decreased by 5.8% and 0.9% for HDBR group and HDBR and exercise group respectively. HOP/Cr significantly increased in the HDBR group and was significantly higher than the HDBR exercise group. BGP decreased in both groups with no significant difference. Conclusion Exercise during 21 d -6°HDBR is beneficial in preventing bone loss.

关 键 词：模拟失重 头低位卧床 骨质丢失 防护效果 骨密度 骨钙素 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]