强骨抗萎方对模拟失重大鼠骨及相关组织生化指标的影响  

Effects of "Qiang Gu Kang Wei" Compound Prescription on Biochemical Indices of Bone and Related Organs in Rats under Simulated Weightlessness.

作　　者：李勇枝[1] 石宏志[1] 范全春[1] 白桂娥[1] 段渊儒[1] 谢俊水[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》2003年第2期103-106,共4页Space Medicine & Medical Engineering

基　　金：中国载人航天工程资助项目

摘　　要：目的研究中药复方强骨抗萎方对尾吊大鼠骨及相关组织生化指标的影响 ,为失重骨丢失的防护提供依据。方法用大鼠尾吊 - 3 0° 2 1d模拟失重 ,观察强骨抗萎方对大鼠血清钙 (Ca)、磷 (P)、血清和骨组织骨钙素 (BGP)、骨羟脯氨酸 (Hyp)、血清、小肠和骨组织碱性磷酸酶 (ALP)等生化指标的作用。 结果与正常对照组比较 ,悬吊组大鼠血清Ca降低 (P <0 .0 5 ) ,P有降低趋势 ;血清、骨组织BGP均减少 (P <0 .0 5 ) ;骨Hyp含量减少 (P <0 .0 5 ) ;血清、小肠和骨组织ALP活性均明显降低 (P <0 .0 1或P <0 .0 5 )。与悬吊组比较 ,中药复方不同剂量显示了不同的作用。该方各剂量组 (3 0 g/kg ,2 0 g/kg ,1 0 g/kg)血清Ca、P均呈不同程度升高 (P <0 .0 1或P <0 .0 5 ) ;血清、骨组织BGP含量均增高或有增高趋势 (P <0 .0 5 ) ;中、小剂量组骨Hyp含量增加 (P <0 .0 5 ) ;骨和血清、小肠组织ALP活性均有不同程度增强 ,但仅有小剂量组差异显著 (P <0 .0 5 )。结论该方具有改善尾吊大鼠骨及血清、小肠等相关组织生化指标的作用 ,但无明显的量效关系。Objective To investigate effects of 'Qiang Gu Kang Wei' prescription on biochemical indices of bone and related organs in tail suspended rats. Method Rats were tail suspended( 30°) for 21 d to simulate weightlessness. The effect of this prescription on biochemical indices such as Ca, P in serum,osteocalcin(BGP) in serum and bone, oxyproline hydroxyproline(Hyp) in bone, alkaliphosphatase(ALP) in serum, small intestine and bone in these rats were examined. Result Comparing with the normal control, serum Ca decreased significantly(P<0.05) while serum P showed only a trend to decrease, at the same time BGP dropped in both serum and bone(P<0.05)and Hyp dropped only in bone(P<0.05).There was significant decrease of ALP activity in serum,small intestine and bone(P<0.01 or P<0.05)in suspended rats. The prescription showed different effects with different doses. In all the three dose groups(30 g/kg,20 g/kg,10 g/kg)Ca and P in serum levels increased(P<0.01 or P<0.05),BGP in serum and bone improved(P<0.05)or showed only a trend to increase. ALP activity increased in serum, small intestine and bone(P<0.05). Increase of Hyp in bone was found in the middle and the small dose groups(P<0.05). Conclusion This prescription shows an effect of improving biochemical indices in bone and related organs such as serum and small intestine in tail suspended rats. But no distinct concentration dependence was found.

关 键 词：模拟失重 骨丢失 强骨抗萎方 中药 生化指标 骨钙素 骨羟脯氨酸 碱性磷酸酶 

分 类 号：R852.22[医药卫生—航空、航天与航海医学] R856.2[医药卫生—临床医学]