口服米索前列醇预防产后出血的临床研究  

A clinical study of oral misoprostol in preventing postpartum bleeding

作　　者：吴敬之[1] 吴晶晶[1] 黄翠玉[1] 

机构地区：[1]广东省妇幼保健院妇产科,广州510010

出　　处：《中国基层医药》2003年第5期415-416,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　观察米索前列醇预防产后出血的效果。方法　选择 1 68例足月妊娠分娩、有产后出血高危因素的产妇 ,分为试验组和对照组。试验组 83例 ,在胎儿娩出后 ,立即口服米索前列醇 60 0 μg ;对照组 85例 ,胎儿娩出后注射催产素 1 0IU。观察产后 2h、2 4h出血量。结果　胎儿娩出后 2h平均出血量 ,试验组为1 4 7 2± 74 6ml,对照组为 2 0 3 4± 92 5ml。 2 4h平均出血量 ,试验组为 2 86 2± 77 0ml,对照组为 389 3±1 0 1 4ml,差异有非常显著意义 (P <0 0 1 )。结论　米索前列醇具有比催产素更强的子宫收缩作用 ,能较好地预防产后出血 ,且用药简便。Objective To observe the effect of misoprostol on preventing postpartum bleeding.Methods One hundred and sixty eight fullterm pregnant women with high risk of postpartum haemorrhage were randomly divided into two groups.In study group(n=83),the patients were given misoprostol 600μg orally after dilivery,and in control group(n=85) the patients were given injection of oxytocin(10IU).The postpartum blood loss were collected and measured carefully with in 2 hours and 24 hours after delivery.Results The amount of postpartum blood loss was 147.2±74.6ml in 2 hours and 286.2±77.0ml in 24 hours respectively in study group which was significantly less than that in control group(203.4±92.5ml and 389.3±101.4ml)(P<0.01).Conclusion Misoprostol has a stronger effect on increasing the uterine contraction than that of oxytocin and preventing postpartum haemorrhage.

关 键 词：米索前列醇 预防 产后出血 催产素 出血量 子宫收缩作用 

分 类 号：R714.46[医药卫生—妇产科学]