铂(II)与胺类配合物的合成、晶体结构和抗肿瘤活性研究  

Synthesis,Crystal Structure and Antitumor Activity of Platinum(II) Complexes

作　　者：潘勇军[1] 夏军[1] 杜勇[1] 朱海亮[1] 

机构地区：[1]武汉科技学院环境与化学工程系,湖北武汉430073

出　　处：《武汉科技学院学报》2003年第2期9-13,共5页Journal of Wuhan Institute of Science and Technology

基　　金：武汉科技学院资助项目 (项目编号:023068).

摘　　要：研究铂(II)与三种胺类配合物的合成、晶体结构和体外抗肿瘤活性,化合物1的X-射线单晶结构分析表明:这是一个很少见的具有四方锥几何构型的铂(II)配合物,顺式平面四方形配位的铂的轴向上有第5个配位原子。其抗肿瘤活性实验显示3个配合物对几种研究的癌细胞都有较强的抑制作用。Three Cis-Platinum (II) complexes of amines (L) have been prepared and structurally characterized and activity determined, where L is hexamethlene-diamine, hexamethylene-tetramine and pyridine. Crystal structure of [Pt(H2O)3Cl(C6H12N4)]Cl was determinated by x-ray single analysis, indicating that it is a cis-compound. The result of antitumor activity assay indicated that complexes 1~3 strongly inhibit the growth of several human solid carcinoma cell lines. Their anti-tumor activities are possibly related to the amount and the emplacement of Pt(II) in the complexes.

关 键 词：铂配合物 胺类 合成 抗肿瘤活性 晶体结构 细胞毒性 抗癌药物 四方锥几何构型 

分 类 号：R979.1[医药卫生—药品] R914.5[医药卫生—药学]