禾草灵对映异构体在高效液相色谱手性固定相上的拆分  

Enantiomeric Resolution of Diclofop-methyl by HPLC with Chiral Stationary Phase

作　　者：陈平[1] 纳鹏君[1] 韩小茜[1] 潘灿平[2] 侯经国[1] 杜新贞[1] 高锦章[1] 

机构地区：[1]西北师范大学化学化工学院 [2]中国农业大学色谱中心,北京100094

出　　处：《分析测试学报》2003年第3期39-41,共3页Journal of Instrumental Analysis

基　　金：西北师范大学科技创新基金资助项目(KJCX -01)

摘　　要：合成了手性纤维素_三(4_甲基苯甲酸酯)(CTMB),并涂敷于氨丙基硅胶上,制备成手性固定相(CSP) ;用高效液相色谱法在该手性固定相上对农药禾草灵外消旋体进行了拆分 ;考察了流动相组成、温度、醇效应对禾草灵对映体拆分及保留的影响 ,由实验结果对禾草灵对映体之间的 -(ΔG )R,S、(ΔH )R,S、(ΔS )R,S 进行了计算 。Cellulose tris(4 _ methylbenzoate) was synthesized by the reaction of microcrystalline cellulose with 4 _ methyl benzoyl chloride. A chiral stationary phase was prepared by coating cellulose tris(4 _ methylbenzoate) on an aminopropyl silica gel. On the chiral stationary phase(CTMB _ CSP), a pesticide diclofop _ methyl enantiomers were separated in a normal _ phase system. The influence of the compositions of mobile phase, column temperature and the sort of alcohols were investigated. -(ΔG)R,S, (ΔH)R,S,(ΔS)R,S values between the enantiomers were calculated and retention mechanism was discussed.

关 键 词：禾草灵 对映异构体 高效液相色谱 手性固定相 手性拆分 除草剂 

分 类 号：TQ457.2[化学工程—农药化工]