二{氧合-二[2-呋喃甲酸二苄基锡(IV)]}的合成、性质及晶体结构  

Synthesis, Anti-tumour Properties and Crystal Structure of Bis{oxo-bis[(2-furylcarboxylato)dibenzyltin(IV)]}

作　　者：尹汉东[1] 王传华[1] 马春林[1] YIN Han-Dong;WANG Chuan-Hua;MA Chun-Lin(Department of Chemistry,Liaocheng University,Liaocheng 252059)

机构地区：[1]聊城大学化学系,聊城252059

出　　处：《有机化学》2003年第5期475-478,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20271025);教育部骨干教师基金;山东省自然科学基金(No.Z2001B02)资助项目.

摘　　要：以二苄基氧化锡和2呋喃基羧酸反应,合成了新的化合物二{氧合-二[2呋喃甲酸二苄基锡(IV)]}.生物活性测试结果表明,该配合物具有较强的体外抗癌活性.X射线单晶衍射测定表明,配合物是以Sn_(2)O_(2)四元环为中心的、中心对称的二聚体结构,内环锡为六配位的畸变八面体结构,外环锡为五配位的加帽畸变三角双锥结构.Bis{oxo-bis[(2-furylcarboxylato)dibenzyltin(IV)]}was synthesized by the reaction of 2-furylcarboxylic acid with the(PhCH_(2))_(2)SnO.The compound was tested against two human tumour cell lines:MCF-7 and WiDr.The results showed that this compound had higher activities in vitro.The crystal structure was determined by X-ray diffraction study.The compound possesses centrosymmetric dimer structure mode with a four-member central endo-cyclic Sn 2O 2 unit in which the bridged oxygen atoms are tri-coordinated.Each bridged oxygen atom also connects with an exo-cyclic tin atom.The endo-cyclic tin atoms are six-coordination and have coordination geometry of distorted octahedron.The exo-cyclic tin atoms are five-coordinate and have coordination geometry of monocapped trigonal bipyramid with very similarly distorted mode.

关 键 词：有机锡 杂环羧酸 合成 晶体结构 

分 类 号：O627.42[理学—有机化学]