A New Cytotoxic Acetogenin from the Seeds of Annona squamosa  

作　　者：Hai Hui XIE, Xiao Yi WEI*, Ji Dong WANG, Mei Fang LIU, Ren Zhou YANG South China Institute of Botany, Chinese Academy of Sciences, Guangzhou 510650 

出　　处：《Chinese Chemical Letters》2003年第6期588-590,共3页中国化学快报（英文版）

摘　　要：A new Annonaceous acetogenin, squamostolide (1), was isolated from the seeds of Annona squamosa. Its structure was elucidated based on spectroscopic methods and comparison with known compounds. It is the first example of Annonaceous acetogenin with each of the two ends of the aliphatic chain bearing a g-lactone. The new compound exhibited cytotoxic activity in vitro against bel-7402 and CNE2 human tumor cell lines.A new Annonaceous acetogenin, squamostolide (1), was isolated from the seeds of Annona squamosa. Its structure was elucidated based on spectroscopic methods and comparison with known compounds. It is the first example of Annonaceous acetogenin with each of the two ends of the aliphatic chain bearing a g-lactone. The new compound exhibited cytotoxic activity in vitro against bel-7402 and CNE2 human tumor cell lines.

关 键 词：Annona squamosa ANNONA ACETOGENINS squamostolide cytotoxicity. 

分 类 号：O629[理学—有机化学]