终止10～18周妊娠三种用药方案效果比较  

A Comparative Study of Medical Abortion to 10 ～ 18 Weeks Gestation

作　　者：向大森 杨志强[1] 邹艳[1] 张辛[1] 曾穗[1] 

机构地区：[1]山东省济南市计划生育服务中心,250002

出　　处：《中国计划生育学杂志》2003年第5期299-302,共4页Chinese Journal of Family Planning

摘　　要：日的:探讨米非司酮配伍米索前列醇终止10～18周妊娠较为理想的用药方案。方法:337例受试者随机分为三组:组Ⅰ(101例)米非司酮口服25m/12h共6次,第4天上午口服米索0.6mg;组Ⅱ(95例)米非司酮口服同组Ⅰ,第4大上午阴道给米索0.6mg;组Ⅲ(141例)米非司酮口服早50mg、晚25mg共2天,第3天上午口服米索0.6mg。结果:①完全流产率组Ⅰ、组Ⅱ、组Ⅲ分别为95.05％、95.78％、92.81％。各组间无显著性差异(P>0.05);②米索用量多少与妊娠周数密切相关,随孕周增 加,用量相对增加,娩出时间延长(P<0.05)。结论:米非司酮配伍米索终止lO～18周妊娠安全、有效,有望取代或部分取代钳刮术,米索阴道用药效果好。Objective:To explore the ideal regimes of mifepristone combined with misoprostol for termination 10 ~ 18 weeks of gestation. Methods: 337 subjects with 10-18 weeks gestation were randomly assigned to three groups. 101 subjects in Group Ⅰ took 25mg mifepristone twice a day for three days, 0. 6mg misoprostol administered orally in the forth morning. 95 subjects in Group Ⅱ took 25mg mifepristone twice a day for three days, 0. 6mg misoprostol administered vaginally in the forth morning. 141 subjects in Group Ⅲ took 50mg mifepristone in the morning and 25mg mifepristone at night for two days, 0. 6mg misoprostol administered orally in the third morning. Results:The successful abortion rates of Group Ⅰ Group Ⅱ and Group Ⅲ were 95. 05% ,95. 78% ,92. 81% respectively, and there were no significant differences between groups. The dose of mifepristone was positively related to weeks of gestation. Conclusion: Taking Mifepristone followed by vaginal misoprostol is safe and effective for termination 10 ~ 18 weeks of gestation, and may be substitute for uterine curettage.

关 键 词：10—18周妊娠 用药方案 比较 终止妊娠 米非司酮 米索前列醇 引产 随访 

分 类 号：R719.3[医药卫生—妇产科学]