Fas FasL TRAIL分子在尖锐湿疣皮损中的分布  

Expression of Fas、FasL and TRAIL Molecules in Lesions of Condyloma Acuminlata

作　　者：谢红付[1] 冯浩[1] 范学工[2] 肖满兰[1] 陈翔[1] 施为[1] 

机构地区：[1]湘雅医院皮肤科,湖南长沙410005 [2]湘雅医院传染科,湖南长沙410005

出　　处：《中国皮肤性病学杂志》2003年第3期151-153,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的　探讨Fas、FasL和TRAIL介导的细胞凋亡在尖锐湿疣发病中的可能作用及意义。方法　用免疫组化方法检测了 30例尖锐湿疣患者皮损中Fas、FasL和TRAIL的表达。结果　所有尖锐湿疣标本 ( 10 0 % )Fas均阳性 ,2 3例 ( 76 .7% )FasL阳性 ,2 1例 ( 70 .0 % )TRAIL阳性 ,三者分布基本一致 ,正常表皮基本不表达。且FasL和TRAIL分子与真皮单一核细胞浸润呈显著负相关 (γ =-0 .5 0 6和γ =-0 .45 0 ,P均 <0 .0 5 )。结论　尖锐湿疣组织中细胞凋亡相关分子Fas、FasL和TRAIL表达异常 ,且Fas、TRAIL分子表达影响局部免疫反应 ,考虑凋亡失控可能参与尖锐湿疣发病 ,引起复发。Objective To investigate the role of the expressions of Fas、FasL and TRAIL molecule in lesions of condyloma acuminata. Methods Fas、FasL and TRAIL molecules in 30 cases with condyloma acuminata were determined by immunohistochemistry.Results The expression of Fas was seen in all(100%)of specimen.23 cases(76.7%) were FasL positive,and 21cases (70%)were TRAIL positive.There was reduced infiltration of mononuclear cells(MNCS) in the epidermis with intensive.FasL and TRAIL staining and was a statistically significant inverse correlation(γ=-0.506 and γ=-0.450 respectively,P<0.05)between them.Conclusion Fas、FasL and TRAIL may involve in the regulation of apotosis and may play an important role in the occurence and recurrence condyloma acuminata.

关 键 词：FAS FASL TRAIL 尖锐湿疣 皮损 细胞凋亡 人乳头瘤病毒 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]