江浙沪地区汉族人群HLA单体型研究  

Study on HLA Haplotypes in Jiangsu-Zhejiang-Shanghai Han Population

作　　者：冯明亮[1] 季芸[1] 陆琼[1] 杨剑豪[1] 谢军华[1] 嵇月华[1] 张工梁[1] 杨颖[1] 

机构地区：[1]上海市血液中心,上海200051

出　　处：《Acta Genetica Sinica》2003年第6期584-588,共5页

摘　　要：利用HLA血清学和分子生物学分型方法对江浙沪地区汉族人群 16 6对夫妻进行HLA A ,B和DRB1单体型调查 ,并分析HLA单体型的分布特征。结果显示 ,江浙沪地区汉族人群HLA A2 ,A11,A2 4 ,B13,B4 6 ,B6 0 ,DRB1 0 4 ,DRB1 0 8,DRB1 0 9,DRB1 12和DRB1 15有较高的频率分布 ( >10 % )。研究中发现HLA A B ,B DRB1单体型分别有 12 8条和 182条 ,占理论单体型总数的 19 2 8% ( 12 8 6 6 4 )和 2 7 4 1% ( 182 6 6 4 )。其中有 18种A B单体型频率大于 0 5 % (连锁不平衡参数△ >0 ) ,有 2 3种B DRB1单体型频率大于 0 5 % (△ >0 )。A B DRB1单体型有 35 1条 ,占理论单体型总数的 5 2 86 % ( 35 1 6 6 4 ) ,其中 8种单体型频率大于 0 5 % (△ >0 ) ,A 30 B13 DRB1 0 7( 4 2 2 % ) ,A2 B4 6 DRB1 0 9( 3 77% ) ,A33 B5 8 DRB1 17( 3 0 1% ) ,A33 B5 8 DRB1 13 1( 1 81% )和A11 B75 DRB1 12( 1 5 1% )是最常见单体型。江浙沪地区汉族人群HLA单体型有其自身分布特点 ,遗传特征介于南北汉族之间 。This study is to investigate HLA haplotypes in Jiangsu Zhejiang Shanghai Han population based on 166 families by serological and molecular biological HLA typing methods and to analyze the distribution characteristic of HLA haplotypes.The results showed that allele frequencies of more than 10% for HLA antigens were A2,A11,A24,B13,B46,B60, DRB1 04, DRB1 08, DRB1 09, DRB1 12 and DRB1 15.In the analysis of HLA haplotypes,128 kinds of A B haplotypes and 182 kinds of B DRB1 haplotypes were found,comprising 19 28%(128/664) and 27 41%(182/664) of total theoretical haplotypes,respectively.18 kinds of A B haplotypes and 23 kinds of B DRB1 haplotypes occurred at frequencies of more than 0 5% (linkage disequilibrium value,Δ>0).351 kinds of A B DRB1 haplotypes were found,comprising 52 86%(351/664) of total theoretical haplotypes,and 8 kinds of A B DRB1 haplotypes occurred at frequencies of more than 0 5% (△>0).The common A B DRB1 haplotypes were A30 B13 DRB1 07(4 22%),A2 B46 DRB1 09(3 77%),A33 B58 DRB1 17(3 01%),A33 B58 DRB1 13 1(1 81%) and A11 B75 DRB1 12(1 51%).The HLA haplotype distribution of Jiangsu Zhejiang Shanghai Han population has its own genetic characteristics,so it suggests this population is between southern and northern Han population.The HLA polymorphism of Chinese Han population is more abundant in East Asian populations.

关 键 词：江浙沪汉族 HLA单体型 单体型频率 基因频率 连锁不平衡参数 

分 类 号：Q987[生物学—遗传学]