蒙药益肾散和保肾散的抗炎作用及其急性毒性  

The Anti-inflammatory Effect and Acute Toxicity of Yishen Powder and Baoshen Powder

作　　者：吴吉英[1] 张化恩[2] 白玉霞[1] 

机构地区：[1]内蒙古民族大学蒙医药学院 [2]内蒙古民族大学医学院,内蒙古通辽028000

出　　处：《内蒙古民族大学学报（自然科学版）》2015年第5期424-427,共4页Journal of Inner Mongolia Minzu University：Natural Sciences

基　　金：内蒙古自治区科技重大专项(ZDZX20130810);通辽市与内蒙古民族大学科技合作项目(SXZD2012011);内蒙古民族大学研究生科研创新资助项目(10136201415)

摘　　要：目的:研究蒙药益肾散和保肾散联合用药的的抗炎作用及其急性毒性.方法:采用二甲苯致小鼠耳廓肿胀及鸡蛋清致大鼠足肿胀的方法,观察其抗炎作用;对益肾散和保肾散进行最大耐受量试验.结果:益肾散和保肾散联合用药中、高剂量均能明显减轻二甲苯致小鼠耳廓肿胀(P<0.05).低剂量能显著减少致炎后0.5h,1h,2h大鼠足肿胀(P<0.05),中剂量能显著减少致炎后0.5h,1h,2h,4h,6h大鼠足肿胀(P<0.05,P<0.01),高剂量能显著减少致炎后0.5h,1h大鼠足肿胀(P<0.05).益肾散最大耐受量是成人临床用量的288倍,保肾散为369倍.结论:益肾散和保肾散联合用药具有抗炎作用,该两种药均无急性毒性.Objective:To study the anti-inflammatory effect and acute toxicity of combination of Yishen powder(Y) and Baoshen powder(B). Methods:The mouse auricle swelling was induced by xylene and the rat foot swelling was induced by egg-white, they were orally given Y combined with B, the anti-inflammation effects of the two drugs were observed, and the acute toxicity of the two drugs were checked by the maximal tolerance dose test. Results:The me-dium dose and high dose of Y and B could significantly reduce xylene-induced mouse auricle swelling;low-dose of Y and B could significantly reduce rat foot swelling after egg white-induced inflammation 0.5h, 1h, 2h(P<0.05), the medium dose could significantly reduce rats foot swelling after inflammation 0.5h, 1h, 2h, 4h, 6h(P<0.05, P<0.01), the high doses could significantly reduce rats foot swelling after inflammation 0.5h, 1h(P<0.05). The maxi-mal tolerance dose of Y was 288 times of clinical adult dosage, of B was 369 times of clinical adult dosage. Conclu-sion:Combination of Y and B has a significant anti-inflammatory effect and has no significant acute toxicity.

关 键 词：益肾散 保肾散 抗炎 急性毒性 

分 类 号：R285.5[医药卫生—中药学]