益寿调脂片对原发性高脂血症脂质调节的影响  

Regulatory Effect of Yishou Tiaozhi Tablet on Lipids in Patients with Primary Hyperlipidemia

作　　者：孙立[1] 姜杰[1] 陈孝银[1] 张荣华[2] 郑仕副[2] 朱秉匡[2] 

机构地区：[1]暨南大学医学院中医学系,广州510632 [2]暨南大学附属第一医院

出　　处：《中国中西医结合杂志》2003年第4期272-274,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：广东省中医药管理局资助课题 (No .960 56) ;国务院侨办资助课题 (No .93 - 95 - 4 7)

摘　　要：目的 :探讨益寿调脂片对原发性高脂血症血脂及脂蛋白的调节作用。方法 :临床选取 16 8例原发性高脂血症患者 ,随机分成两组 ,治疗组服用益寿调脂片 ,每次 4片 ,每天 3次 ;对照组服用舒降之 ,每天 1片 ,睡前服 ;两组疗程 6 0天。观察其疗效及对脂质调节的影响。结果 :治疗组对降低胆固醇 (TC)、甘油三酯(TG)、低密度脂蛋白胆固醇 (LDL C)、动脉硬化指数 (AI)、载脂蛋白B(apoB)疗效显著 ,并能显著降低TC/HDL C及升高apoA/apoB的比值。其中 ,TC、AI、apoB疗效与舒降之比较差异无显著性 (P >0 0 5 ) ;而TG疗效明显优于舒降之 (P <0 0 1) ,LDL C的疗效则不如舒降之显著 (P <0 0 1)。对升高高密度脂蛋白胆固醇 (HDL C) ,两组疗效均不理想。本方治疗高脂血症的总有效率为 91 9% ,个体疗效中除降TG和升高HDL C作用明显强于舒降之组外 ,其余治疗效果与舒降之组比较差异均无显著性。治疗期间本方剂不良反应轻微 ,不影响继续用药。结论 :益寿调脂片对原发性高脂血症患者的血脂及脂蛋白有一定的调节作用。Objective:To study the regulatory effect of Yishou Tiaozhi Tablet (YSTZT) on blood lipids in patients with primary hyperlipidemia. Methods:One hundred and sixty-eight patients with primary hyperlipidemia were randomly divided into two groups. The treated group was treated with YSTZT 4 tablets 3 times a day, and the control group was treated with Zocor by oral taking 1 tablet before sleep every evening. The therapeutic course for both groups was 60 days. The effect in regulating blood lipids in patients was observed. Results:The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), arteriosclerosis index (AI), apo-lipoprotein B (apoB), TC/HDL-C lowered and apoA/apoB ratio increased obviously in the treated group. As compared the effects between the two groups, the lowering of TC, AI and apoB in the two groups were similar (P>0.05), effect of YSTZT in lowering TG was superior but in lowering of LDL-C was inferior to those of Zocor respectively (all P<0.01). The effect of both remedies in elevating HDL-C was not satisfactory. The total effective rate of YSTZT was 91.9%, its individual effects were similar to those of SJZ respectively except in lowering TG and raising HDL-C. The adverse reaction occurred in YSTZT treatment course was mild without any influence on the medication. Conclusion:YSTZT had definite regulatory effect on the blood lipids and lipoproteins in patients with hyperlipidemia.

关 键 词：原发性高脂血症 益寿调脂片 中药制剂 脂质调节 胆固醇 甘油三酯 低密度脂蛋白胆固醇 动脉硬化指数 载脂蛋白B 

分 类 号：R259.8[医药卫生—中西医结合]