蒺藜皂苷对高脂血症的影响  

Effect of Saponin from Tribulus terrestris on Hyperlipidemia

作　　者：褚书地[1] 瞿伟菁[1] 逄秀凤[1] 孙斌[1] 黄晓青[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《中药材》2003年第5期341-344,共4页Journal of Chinese Medicinal Materials

摘　　要：以高脂饲料诱导高脂血症小鼠模型,研究了蒺藜皂苷的调血脂作用。研究表明:蒺藜皂苷能降低实验性高脂血症小鼠血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及肝脏胆固醇、甘油三酯的含量;在灌胃蒺藜皂苷的同时继续喂食高脂饲料,能有效地阻止血清胆固醇、低密度脂蛋白胆固醇(LDL-C)的升高,同时能降低肝脏胆固醇、甘油三酯的含量,提高肝脏超氧化物歧化酶的(SOD)的活性。The preventive and therapeutic effects of saponin from Tribulus terrestris L. on diet-induced hyperlipidemia in mice have been studied. It showed that in preventive experiment the saponin could significantly low the levels of serum TC (P < 0. 05 ) , LDL-c ( P < 0. 01) and liver TC ( P < 0. 05 ) , TG ( P < 0. 05 ) , and increase the activities of superoxide-dismutase ( SOD ) in liver. The therapeutic experiment showed that the saponin could significantly reduce the contents of serum TC ( P < 0. 05 ) and liver TC

关 键 词：蒺黎皂苷 高脂血症 甘油三酪 低密度脂蛋白胆固醇 胆固醇 小鼠 实验研究 

分 类 号：R259.892[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]