Von Willebrand因子、C反应蛋白和肌钙蛋白Ⅰ在冠状动脉支架置入术后的变化  

Changes of Von Willebrand factor, C-reactive protein and Troponin Ⅰ in patients undergoing coronary stenting

作　　者：于宗良[1] 杨向军[1] 李勋[1] 惠杰[1] 蒋廷波[1] 宋建平[1] 刘志华[1] 蒋文平[1] 

机构地区：[1]苏州大学附属第一医院心内科,苏州215006

出　　处：《中国血液流变学杂志》2003年第2期114-116,共3页Chinese Journal of Hemorheology

摘　　要：目的　探讨冠状动脉支架置入术 (CS)前后血液中VonWillebrand因子 (vWF)、C反应蛋白 (CRP)和肌钙蛋白I(cTnI)浓度的变化对病情判断的意义 ,以及各指标间的联系。方法　 2 2例CS术患者 ,随访 3～ 12月 ,根据临床症状、心电图和冠脉造影等检查分为再狭窄组 ( 6例 )和无再狭窄组 ( 16例 )。分别在手术前后 2 4小时取血测vWF、CRP和cTnI。结果　两组术后三指标均升高 ,再狭窄组术前和术后的变化都高于无再狭窄组 ,术后的vWF和CRP显著相关。结论　vWF、CRP和cTnI可作为CS术前后判断病情的有效指标。Objective To study blood changes of vWF, CRP and cTnI in patients undergoing coronary stenting (CS), and their effectiveness in evaluating patients' condition. Methods 22 patients undergoing CS were followed up 3～12 months. 6 of them with recurrence of angina because of restennosis were defined to group A, the others without recurrence of angina were group B. All patients' plasm levels of vWF, CRP and cTnI were determinated 24 hours before and after CS. Results The outcome showed that levels of three indictors were higher in group A than those of group B before and after CS. The levels of vWF and CRP after CS had a significant correlation after CS. Conclusion Plasm levels of vWF, CRP and cTnI may be useful indictors in evaluating patients' condition who undergoing CS.

关 键 词：VONWILLEBRAND因子 C反应蛋白 肌钙蛋白Ⅰ 冠状动脉支架置入术 

分 类 号：R541.4[医药卫生—心血管疾病]