焦炉工人职业性肺癌病因再探讨  

A Further Study on Etiology of OccupationalLung Cancer among Coke Oven Workers

作　　者：耿秀娥[1] 程海明[1] 周慧[1] 王玉民[1] 

机构地区：[1]山西省疾病预防控制中心,山西太原030012

出　　处：《工业卫生与职业病》2003年第3期144-145,共2页Industrial Health and Occupational Diseases

基　　金：山西省重点攻关课题 92 ( 15 2)

摘　　要：目的　进一步探讨焦炉工人职业性肺癌的病因。方法　采用多种致癌因子诱发小鼠肺癌的实验。结果　二苯并 [a ,h]蒽的致癌作用强于苯并 [a]芘 ,五环烃同焦尘相复合后 ,致癌作用呈现相加效应。结论　五环烃 ,尤其是二苯并 [a,h]蒽 ,作为多环芳烃致癌原的代表 ,是焦炉工人职业性肺癌的主要病因。Objective To further explore the etiology of occupational lung cancer among coke oven workers. Methods Induce mice lung cancer by different kinds of carcinogens.Results DB[a,h]A is more carcinogenic than B[a]P . Carcinogenic effect might be increased by exposure to pentacyclic hydrocarbons and coke dust simultaneously.Conclusions The pentacyclic hydrocarbons,especially the DB[a,h]A, a representative carcinogen of this group,might be the main carcinogen for occupational lung cancer among coke oven workers.

关 键 词：焦炉工人 职业性肺癌 病因 二苯并[a h]蒽 五环烃 

分 类 号：R135.2[医药卫生—劳动卫生] R734.2[医药卫生—公共卫生与预防医学]