表面机械处理纳米化对改善钛基植入物材料机械及生物学性能的研究进展  

Research advance of titanium alloys with surface nano-crystal modification by mechanical process on mechanical property and biocompatibility

作　　者：朱文俊[1] 曾莉[2] 曹小建[3,4] 丁华建[3] 

机构地区：[1]南通大学医学院,南通226001 [2]江苏省南通市妇幼保健院妇产科 [3]南通大学建筑工程学院 [4]四川大学建筑与环境学院

出　　处：《南通大学学报（医学版）》2015年第4期286-289,共4页Journal of Nantong University(Medical sciences)

基　　金：国家自然科学青年基金资助项目(11202108);中国博士后基金资助项目(2014M552355);江苏省高校自然科学研究面上项目(13KJB130002)

摘　　要：表面机械处理使钛基植入物表面晶粒尺寸通过强塑性变形逐步细化到纳米量级。纳米表面可增加材料表面粗糙度、减小表面孔隙尺寸、提高表面活性及表面能,从而增强细胞黏附能力、提高蛋白质吸附能力、促进骨再生。本文介绍了机械处理致表面纳米化的原理及其对钛基材料机械性能的影响,重点对表面机械处理致纳米化后钛基植入物材料生物学性能的研究进展进行了归纳,以便为相关研究提供信息。Severe plastic deformation induced by mechanical surface treatment can make the surface grain size of Tibased implant materials progressively transformed into nanoscale. Surface nano-crystal modification increases the surface roughness, the surface activity and the surface energy. And it reduces the surface pore size at the same time. The surface nanostructure can improve cell adherence, protein adsorption. It also promotes the osteanagenesis. The principle of surface nano-crystal modification by mechanical process and the effect of this technology on titanium alloys are introduced. This paper mainly reviews the research progress of the biocompatibility of Ti-based implant materials which subjected with surface nano-crystal modification, in order to provide information for related research.

关 键 词：表面纳米化 钛合金 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]