消心痛胶囊对急性心肌缺血大鼠心电图ST段和T波变化影响的研究  

Effects of Xiaoxintong capsule (消心痛胶囊) on electrocardiogram segment ST and wave T of rats with acute myocardial ischemia

作　　者：滕久祥[1] 陈晓阳[1] 蒋孟良[1] 彭芝配[1] 韩国栋[1] 孙贵香[1] 

机构地区：[1]湖南中医学院,湖南长沙410007

出　　处：《中国中西医结合急救杂志》2003年第3期161-163,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：湖南省中医药管理局科研基金资助项目 ( 2 0 0 2 0 0 6)

摘　　要：目的 :探讨消心痛胶囊对心肌缺血模型大鼠心电图 ST段和 T波抬高及其抬高超过 0 .2 m V的时间和发生率的影响。方法 :采用舌下静脉注射脑垂体后叶素制备大鼠急性心肌缺血模型 ,以心电图 导联 ST段和 T波变化作为观察指标 ,观察消心痛及地奥心血康胶囊对大鼠缺血心肌的改善作用 ,并比较两种药物的疗效。结果 :消心痛胶囊组能明显降低心肌缺血大鼠心电图 ST段和 T波的抬高值 (P均 <0 .0 5 ) ;并使 ST段和 T波抬高超过 0 .2 m V的时间缩短、发生率减少 (P均 <0 .0 5 ) ;高剂量消心痛组与地奥心血康组作用接近。高剂量消心痛胶囊组在 1 min时间段即能明显降低垂体后叶素所致的 ST段和 T波抬高 (P均 <0 .0 1 )。结论 :消心痛胶囊有良好抗心肌缺血的预防及治疗作用 ;这可能与其扩张冠状动脉 (冠脉 ) ,增强冠脉血流量 ,改善心肌供血 。Objective: To investigate effects of Xiaoxintong capsule on electrocardiogram(ECG) segment ST, elevation of wave T, time and incidence of segment ST and wave T in excess of 0 2 mV. Methods: Rat's acute myocardial infarction(AMI) model was built by using the Pituitrin of hypophysis cerebri. Segment ST and wave T of ECGⅡ were observed as the indexes of the AMI improvement in the medical group. The effects of Xiaoxintong capsule and Diao Xinxuekang capsule were observed. Results: Compared to model group, Xiaoxintong capsule could greatly improve the elevation of segment ST and wave T of the ischemia( P <0 05), reduce the incidence and the time for elevation(both P <0 05). The effect was almost the same between high dosage of Xiaoxintong capsule group and Diao Xinxuekang capsule group. At different time slot, compared to the model group, high dosage of Xiaoxintong capsule group had an obvious significance within one minute (all P <0 01). It could significantly descend the elevation of segment ST and wave T caused by Pituitrin of hypophysis cerebri. Conclusion: Xiaoxintong capsule has good preventive and therapeutic effects of antimyocardial ischemia. It maybe associate with the function of expanding coronary artery, enhancing blood circulation, improving the blood supply of the heart muscle and its endurance of the oxygen deficiency and regulating the balance of the whole organism.

关 键 词：消心痛胶囊 急性心肌缺血 大鼠 心电图 ST段 T波 冠心病 脑垂体后叶素 地奥心血康胶囊 

分 类 号：R285.5[医药卫生—中药学] R259.422[医药卫生—中医学]