超声软指标及血清学筛查胎儿染色体病的临床价值  

The clinical value of ultrasound soft targets and serological screening for fetal chromosomal disease

作　　者：杜鹏[1] 芮淑贤[2] 王微[1] 李婵[1] 丁莉莉[2] 纪学芹[2] 潘丽华[2] 

机构地区：[1]宁夏医科大学,宁夏银川75004 [2]宁夏医科大学总医院,宁夏银川750004

出　　处：《宁夏医学杂志》2016年第6期503-505,共3页Ningxia Medical Journal

摘　　要：目的应用超声筛查软指标异常和血清学筛查两种方法筛查染色体异常,以评估其临床应用的价值。方法选取定期产检的孕妇3 015例,记录孕妇血清学筛查及孕期超声结果、染色体核型分析结果及新生儿随访情况。结果 3 015例接受筛查孕妇中,血清学筛查高风险者171例,孕期B超存在超声软指标者123例,染色体核型分析显示异常21例,发生率为0.69%(21/3 015);4组筛查方法的正确指数,分别为0.66、0.34、0.14和0.87;染色体数目异常7例(3.76%),染色体结构异常8例(4.30%)。结论将超声软指标阳性及血清学筛查高风险任何一项作为筛查指标进行诊断,可降低染色体异常的漏诊率,两种方法联合,可提高其敏感度。Objective To assess the clinical value of two ways of ultrasound soft targets and serological screening for chromosomal abnormalities. Methods 3 015 cases regular check were selected by inclusion and exclusion standards. Recorded serological screening of pregnant women and pregnancy ultrasound findings,karyotype analysis results and newborn children were followed up the case. Results In 3 015 screened cases,serological screening for high risk 171 cases,123 cases of pregnancy ultrasound B super soft targets existed who hare shoved abnormal karyotype analysis in 21 cases; four screening methods right index were respectively 0. 66,0. 34,0. 14 and 0. 87; number of chromosomal abnormalities was 3. 76%( 7 /186),and chromosome structural abnormalities was 4. 30%( 8 /186). Conclusion Ultrasound soft targets and serological screening for fetal chromosomal abnormalities have clinical value,and combination of two methods could increase diagnostic sensitivity.

关 键 词：超声 血清学 筛查 染色体 异常 

分 类 号：R714.5[医药卫生—妇产科学]