溃结灵颗粒治疗活动期溃疡性结肠炎的临床与实验研究  

Clinical and Experimental Research of Kuijieling Granule in Treating Ulcerative Colitis during the Active Period

作　　者：黄志新[1] 劳绍贤[1] 崔琦珍[1] 王汝俊[1] 胡旭光[1] 

机构地区：[1]广州中医药大学脾胃研究所,广州510405

出　　处：《中国中西医结合消化杂志》2003年第3期141-143,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：广东省中医药局科研资助课题(No.101049)

摘　　要：目的:通过临床和动物实验探讨溃结灵治疗溃疡性结肠炎(UC)的机制。方法:活动期UC(湿热内蕴证)患者92例随机分为溃结灵组、柳氮磺胺吡啶组(SASP)和中西药结合组,以肠粘膜病变、中医证候疗效、主要症状积分作为观察指标;免疫法造成UC大鼠模型,随机分成空白对照组,SASP组,溃结灵高、中、低剂量组(每组10只)及正常组,作结肠病理观察和血清肿瘤坏死因子-α(TN-α)和白细胞介素-6(IL-6)的检测。结果:溃结灵组对患者的粘膜疗效与SASP组比较差异无显著性意义,但证候疗效明显优于SASP组(P<0.01),总有效率为93.33％;对改善腹泻、腹痛、腹胀、里急后重的作用优于SASP组,且无任何不良反应。溃结灵能减轻UC大鼠炎症,改善粘膜病变,并能减少TNF-α。结论:溃结灵具有确切的治疗UC的作用,这可能与它能减轻炎症、调节炎症因子有关。Objective:To explore the mechanism of Kuijieling granule (KG) in treating ulcerative colitis(UC) during the active period by the clinical and animal experiment. Methods: The patients of active UC (damp-heat syndrome) were randomly divided into 3 groups to observe pathological changes of the mucosa, syndrome effect and main symptoms scores. The rat model of UC was made by immunologic method, which were randomly divided into 6 groups. The colon pathological changes were observed and TNF-α and IL-6 were measured. Results: There was no difference between the mucous effect of KG and that of SASP, while KG had better effect on syndrome improvement( P < 0. 01), and the total effective rate of KG group was 93. 33%. KG could alleviate the inflammation and lower the level of TNF-α in UC rats. Conclusion: KG has definite effect on UC, which may be related with relieving the inflammation and adjusting the cytokines.

关 键 词：溃结灵颗粒 活动期 溃疡性结肠炎 动物实验 火炭母 地榆 田七 治疗 柳氮磺胺吡啶 

分 类 号：R285.5[医药卫生—中药学] R259.746.2[医药卫生—中医学]