狼疮静颗粒对狼疮样小鼠外周血CD4^+、CD8^+及CD54表达的影响  

Effect of Langchuangjing Granule on Expression of CD4^+CD8^+ and CD54 in Peripheral Blood of Lupus Mice

作　　者：朱方石 金实[2] 汪悦[2] 丁炜[2] 周决[3] 许兰文[3] 

机构地区：[1]浙江大学邵逸夫临床医学研究所,浙江310016 [2]南京中医药大学,南京210029 [3]复旦大学医学院,上海200032

出　　处：《中药新药与临床药理》2003年第3期165-168,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：江苏省科技厅自然科学基金课题(编号BS99077);江苏省中医药管理局自然科学基金课题(编号H-032)。

摘　　要：目的探讨狼疮静颗粒不同剂量对自发性狼疮小鼠部分免疫调节作用机制。方法运用狼疮静颗粒3种不同剂量,对3月龄雌性NZB/NZWF1狼疮模型小鼠进行干预治疗6周,观察其对各组小鼠CD4+、CD8+细胞及CD54表达的影响。结果中药狼疮静不同剂量有升高模型小鼠外周血CD4+、CD8+细胞的倾向,能降低血清CD54含量,抑制血浆淋巴细胞表面及单核细胞表面CD54的高表达,其作用以中、高剂量明显。结论狼疮静颗粒能改善和调节自发性狼疮小鼠细胞免疫功能,抑制过亢的免疫反应。Objective To study the immunoregulatory mechanism of Langchuangjing Granule(LG)in different dosages in lupus mice.Methods Three -month female NZB /NZWF1mice were treated with LG in three differen t dosages for six weeks and then the effect of LG on t he expression of CD4 + ,CD8 + and CD54in peripheral blood was obse rved.Re-sults LG in different dosages showed a tend ency of increasing the content of CD4 + and CD8 + ,decreased the serum con-tent of CD54and inhibited the hyper -expressions of CD54on the surface of lymphocyte and monocyte in plasma.T he above effects were stronger in middl e -and high -dosage of LG.Conclusion LG can improve the immune function an d restrain the excessive immunoreaction of lupus mice.

关 键 词：狼疮静颗粒/药理学 NZB/NzW F1小鼠 系统性红斑狼疮/中药疗法 系统性红斑狼疮/病理学 T淋巴细胞 细胞间粘附分子1 

分 类 号：R285.5[医药卫生—中药学]