肿节风注射液抗小鼠前胃癌FC的作用及毒性  

Antitumor Activity of Zhongjiefeng Injection on FC in Mice with Precarcinoma of Stomach and Its Toxicity

作　　者：孙文娟[1] 李晶[2] 兰凤英[3] 杨世杰[2] 

机构地区：[1]重庆医科大学药理教研室,重庆400016 [2]吉林大学基础医学院药理教研室,长春130031 [3]长春医学高等专科学校药理教研室,长春130021

出　　处：《中药新药与临床药理》2003年第3期168-171,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的研究肿节风注射液(ZJF)抗小鼠前胃癌FC的作用及毒性。方法建立小鼠体内荷小鼠前胃癌FC模型,测定ZJF的抑制率和体重、胸腺指数和脾指数以及给药前后外周血白细胞的变化,同时研究ZJF对小鼠前胃癌FC细胞株生长的抑制作用。结果ZJF具有明显的抗肿瘤作用,ipZJF0.2g/kg、1g/kg、0.2g/kg的抑瘤率分别为39.83%、64.41%、53.39%,且能明显升高荷瘤小鼠的脾指数和胸腺指数,升高外周血白细胞,增加荷瘤小鼠的体重。ZJF100mg/mL、50mg/mL、25mg/mL、12.5mg/mL、6.25mg/mL对小鼠前胃癌FC细胞增殖的抑制率分别为65%、63%、57%、55%、44%。结论ZJF体内、外对小鼠前胃癌FC均具有抗肿瘤作用,并可增加荷瘤鼠免疫器官指数及外周血白细胞数。Objective To Study the antitumor activity of Zhongjiefeng injection(ZJF)on FC in mice with precancer of stomach and its toxicity.Methods The model mice transplanted with pre cancer of stomach was established an d the effects of ZJF on inhibitory rate,body weigh t,thymus index and spleen index,whi te blood cell(WBC)count and FC cell strain in model mice were observed.Results ZJF had an obvious antitumor effect.The inhibitory rates of ZJF ip 0.2g /k g,1g /kg and 2g /kg were 39.83%,64.41%and 53.39%respectively.ZJF increased the indexes of spleen and thymus,the amount of WBC and body weight.The inhibitory rates of ZJF ip 100mg /mL,50mg /mL,25mg /mL,12.5mg /mL and6.25mg /mL were 65%,63%,57%,55%and44%respectively.Conclusion ZJF exerts an in -vitro and in -vivo antitumor effect for precancer of stomach in mice and increase the indexes of immune organs and amount of WBC.

关 键 词：肿节风注射液/药理学 小鼠前胃癌FC/中药疗法 免疫系统/药物作用 

分 类 号：R285.5[医药卫生—中药学]