低出生体重儿维生素K干预前后PIVKA-Ⅱ变化的研究  

THE CHANGE OF PIVKA-Ⅱ IN LOW-BIRTH-WEIGHT-INFANTS BY VITAMINE K INTERFERENCE

作　　者：宋华[1] 潘健儿[1] 余文霞[1] 吴玉宇[1] 江洪清[1] 钟红磊[1] 邓筹芬[1] 陈艳娟[1] 

机构地区：[1]广东省江门市妇幼保健院,529000

出　　处：《新生儿科杂志》2003年第2期54-56,共3页The Journal of Neonatology

摘　　要：为了解低出生体重儿(LBWI)生后维生素K情况及治疗后的变化,将50例LBWI随机分为A组(26例)和B组(24例)。两组于生后维生素K治疗前采静脉血检测血浆维生素K缺乏诱导蛋白Ⅱ(PIVKA-Ⅱ)后,A组静注维生素K_11mg,B组静注5mg并于5天后再次采血检测PIVKA-Ⅱ。结果显示A、B组LBWI生后各有8例PIVKA-Ⅱ≥2μg/ml(P>0.05)。经维生素K_1治疗后PIVKA-Ⅱ≥2μg/ml各为2例和1例。两组间统计学处理差异不明显(P>0.05)。但维生素K_1治疗前、后PIVKA-Ⅱ≥2μg/ml分别为16例、3例。统计学处理差异显著。本组LBWI观察期间无一例临床出血病例发生。结论:LBWI生后存在维生素K缺乏。静注维生素K_11mg、即可预防维生素K缺乏的发生。To explore the information of low-birth-weight-infants (LBWI) and the change by Vitamine K treatment, infants were divided randomly into the group A( n = 26)and group B( n = 24). The plasma protein induced by Vitamin K absence of antagonist-Ⅱ(PIVKA-Ⅱ) level was measured at one day of age in all infants . The infants of group A received 1 mg vitamin K by intravenous perfusion. The infants of group B received 5 mg vitamin K1 by intravenous perfusion. The plasma levels of PIVKA-Ⅱ were measured again at the 5th day of age. Results showed infants whose PIVKA-Ⅱ levels ≥2 μg/ml were 8 cases at one day of age in group A and B. After vatamin K treatment, there was significantly improvement in the infants with PIVKA-Ⅱ levels. Before and after vitamin K treatment the positive cases (PIVKA-Ⅱ ≥2 μg/ml) were 16 cases and 3 cases, respectively. The differences was statistically significant(P <0.05). None of the tested infants showed clinical bleeding during the period of observation. LBWI exist low levels of vitamin K dependent factors. LBWI were treated with vitamin K, 1 mg or 5 mg can protect the haemorrhagic diseases of vitamin K deficiency.

关 键 词：低出生体重儿 干预 静脉血 检测 出血性疾病 PIVKA-Ⅱ 维生素K 凝血酶原时间 

分 类 号：R722.1[医药卫生—儿科]