人参二醇组皂甙对肾小管细胞增殖的影响  

Effects of PDS on Proliferation of Renal Tubular Cells

作　　者：刘国红[1] 朱晓燕[1] 杨继要[1] 

机构地区：[1]郑州大学医学院组织胚胎学教研室,河南郑州450052

出　　处：《河南职工医学院学报》2003年第2期10-11,共2页Journal of Henan Medical College For Staff and Workers

摘　　要：目的　探讨人参二醇组皂甙 (Panaxadiolsaponins ,PDS)对肾小管细胞增殖的影响。方法　应用噻唑蓝 (thia zollblue ,MTT)染色法观察PDS对正常的和庆大霉素 (Gentamicin ,GM)损伤的肾小管细胞增殖的影响。结果和结论　在一定浓度范围内 (5～ 2 5 μg/ml)PDS促进正常肾小管细胞增殖 ,10 μg/mlPDS作用最明显。PDS浓度过高 (>75μg/ml)则抑制其生长 (P <0 .0 5 )。Objective To clarify the effects of PDS on proliferation of renal tubular cells.Methods The proliferation of renal tubular cells were observed by MTT staining method.Results and Conclusions PDS at doses of 5～25 μg/ml promoted significantly the proliferation of normal renal tubular cells, moreover, PDS promoted the proliferation of renal tubular cells injured by Gentamicin.

关 键 词：人参二醇组皂甙 肾小管细胞增殖 庆大霉素 肾损伤 实验 

分 类 号：R277.52[医药卫生—中医学] R285.5