补气通络方对大鼠坐骨神经急性挤压伤功能恢复的影响  

THE INFLUENCE OF "BUQI TONGLUO" PRESCRIPTION ON THE FUNCTIONAL RECOVERY IN ACUTE CRUSH INJURY OF RAT SCIATIC NERVE

作　　者：杨志东[1] 韩清明[1] 梁笃[1] 何振辉[1] 梁德[1] 晋大祥[1] 

机构地区：[1]广州中医药大学第一附属医院,510405

出　　处：《中医正骨》2003年第6期3-4,共2页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：广东省中医药管理局资助项目 (编号 :99136 )

摘　　要：为比较补气通络方和神经外膜切开对周围神经急性挤压伤的治疗效果 ,采用清洁级SD大鼠制成精确的右坐骨神经急性挤压伤模型。造模成功后随机分为补气通络胶囊剂组、手术 (神经外膜切开 )组、补气通络胶囊 +手术组和对照组。经过造模给药后 1天、1周、4周、8周作坐骨神经传导速度 (NCV)、阈强度、最大波幅测定作为观测指标 ,判断神经功能的修复情况。结果显示补气通络方及补气通络方 +手术组的坐骨神经传导速度 (NCV)、阈强度、最大波幅均比对照组恢复快 ,有显著性差异 (P <0 .0 5及P <0 .0 1) ;手术 (神经外膜切开 )组虽优于对照组 ,但无统计学意义 (P >0 .0 5 ) ;对照组恢复最慢 ;补气通络方与补气通络方 +手术组之间比较 ,无显著性差异 (P >0 .0 5 )。表明补气通络方对周围神经急性挤压伤后的神经恢复有促进作用 ;单纯神经外膜切开对周围神经急性挤压伤早期可能有帮助 ,但与对照组无显著性差异 ,远期疗效可能因破坏神经营养血管并不确切 ,临床运用价值不大。The objective of the paper is to compare the therapeutic effects of “BUQI TONGLUO” (BQTL) prescription and epineurial incision (EI) on acute peripheral-nerve crush injury. Models of acute crush injury of the right sciatic nerve were made in clean SD rats and randomly divided into four groups: the first, the second, the third and the control, the first three of which were treated by BQTL capsules, by EI, and by BQTL capsules and EI, respectively. One day, one week, four weeks and eight weeks after the modeling and treatment, the nerve-function recovery was evaluated taking the nerve conductive velocity (NCV), the threshold tension (TT), and the maximum amplitude (MA) of the sciatic nerve as the observation indices. The results showed that the recovery of NCV, TT, and MA in the first and third groups was quicker than that in the control with significant differences (P < 0.05 and P < 0.01); the second group had an advantage over the control but had no statistical significance (P > 0.05); the recovery of the observation indices in the control was the slowest; the first and third groups had no significant difference from each other (P > 0.05), suggesting that BQTL prescription could promote the nervous recovery after crush injury to the peripheral nerve; alone of EI could improve the acute crush injury of the peripheral nerve at the early stage but it had no significant difference from the control; and its long-term result was not definite because of the disturbance of the blood supply of th nerve, so it has no great value to the clinical application.

关 键 词：补气通络方 大鼠 坐骨神经急性挤压伤 功能恢复 手术 神经外膜切开 中医药疗法 

分 类 号：R285.5[医药卫生—中药学]