慢性肺心病患者肺动脉血栓形成相关因素分析  

Risk factors of pulmonary arterial thrombosis in patients with Chronic cardiopulmonary disease

作　　者：杨海波[1] 王明明[1] 

机构地区：[1]浙江省舟山市人民医院ICU,316004

出　　处：《浙江临床医学》2003年第6期414-415,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 了解慢性肺心病肺动脉血栓形成的因素。方法 对20例慢性肺心病患者凝血功能指标PT、KPTT、FIB ;反映纤溶指标D -二聚体 ;反映血小板功能的活化血小板、PAgT进行研究 ,并对其急性发作期、缓解期与对照组进行比较。结果 慢性肺心病急性发作期的KPTT缩短 ,FIB、D -二聚体、活化血小板、PAgT升高 ,与对照组比较有显著差异 ,血液处于高凝状态 ,且在缓解期有一定改善。结论 慢性肺心病由于缺氧、肺动脉高压等存在 ,造成血管内皮损伤、血小板功能改变、血液高凝状态 ,容易引起肺动脉血栓形成 。Objective To find out the the risk factor of pulmonary arterial thrombosis in patients with Chronic cardiopulmonary disease. Method 20 patients with Chronic cardiopulmonary disease were employed in our study. The blood coagulation function, Fibrinolysis function and platelet function of all patients were examined at acute episode phase and remission phase, and were compared with that of control group.Result All patients showed a Shortening of KPTT and step-up of FIB, D-dimer, activated platelet and PAgT at acute episode phase. But these changes ameliorated at remission phase. Conclusion exist of hypoxia and pulmonary hypertension may lead to endothelium injury, disfunction of platelet and hypercoagulable state of blood in patient of Chronic cardiopulmonary disease. They are the risk factors of pulmonary arterial thrombosis. Remission of respiratory function may be helpful to ameliorate hypercoagulable state.

关 键 词：慢性肺心病 肺动脉血栓形成 相关因素 D-二聚体 活化血小板 慢性阻塞性肺病 

分 类 号：R541.5[医药卫生—心血管疾病] R543.2[医药卫生—内科学]