糖尿病大鼠海绵体神经诱发电位的实验研究  

Experimental Study of Corpus Cavernosal Nerve Evoked Potential in Diabetic Rats

作　　者：郭凯[1] 王显辉[2] 王毅[3] 王峥屹[1] 张富文[1] 

机构地区：[1]成都中医药大学内科学教研室,四川成都610075 [2]四川省人民医院泌尿外科,四川成都610072 [3]成都中医药大学附属医院病理科,四川成都610072

出　　处：《中华男科学杂志》2003年第3期181-183,共3页National Journal of Andrology

摘　　要：目的 :观察糖尿病 (DM)性大鼠海绵体的神经病变。　方法 :3 5只SD大鼠随机分为造模组 ( 2 5只 )和空白对照组 ( 10只 )。造模组应用腹腔内单次注射链脲佐菌素 ( 63mg/kg)制造DM模型。单波刺激海绵体神经 ,测定反射潜伏期及肌电位。　结果 :海绵体神经 海绵体平滑肌传导潜伏期中 ,DM组所需时间明显长于其他各组 (P <0 .0 1)。同时 ,与其他各组相比 ,其海绵体平滑肌电位明显升高 (P <0 .0 1)。　结论Objectives: To observe the cavernosal nerve dysfunction of diabetic Sprague Dawley rats. Methods: Thirty-five Sprague-Dawley rats were divided randomly into diabetes model group(n=25) and normal group(n=10). Diabetes model was established by administration of streptozotocin (63 mg/kg) in single intraperitoneal dosing. Giving single wave stimulus, corpus cavernosal nerve was measured for its latent period of reaction and myopotential. Results: Compared with other groups, diabetic rats had longer reflection latent period(P< 0.01) and higher corpus cavernosum smooth muscle myopotential (P< 0.01). Conclusions: The results indicate that corpus cavernosal nerve dysfunction may play an important role in the erectile dysfunction of diabetic rats. Natl J Androl,2003,9(3):181-183

关 键 词：海绵体神经 糖尿病 诱发电位 大鼠 

分 类 号：R587.1[医药卫生—内分泌]