老年人血清褪黑素水平变化的探讨  

Study on variation of serum melatonin level in Chinese elders

作　　者：赵子彦[1] 路方红[1] 栾杨[1] 谢毅[1] 付越榕[1] 刘建平[2] 韩凯[3] 张秀芹[1] Yvan Touitou 

机构地区：[1]山东省医学科学院抗衰老研究中心,山东济南250062 [2]解放军济南军区总医院心内科,山东济南250031 [3]章丘市人民医院,山东章丘250200 [4]法国巴黎Pitié-Salpêtrière医学院生物化学及分子生物学系,巴黎75013

出　　处：《中华老年心脑血管病杂志》2003年第3期156-158,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的　探讨老年人血清褪黑素 (松果腺主要在夜间分泌的一种吲哚胺类激素 )水平变化。方法　用放射免疫法检测了 14 4例济南市人 (31～ 110岁 )夜间 (0 2 :0 0 )及白天 (0 8:0 0 )血清褪黑素水平。结果　夜间血清褪黑素水平随着年龄增长呈下降趋势 ,与成年人组比较 70岁组和 >80岁组的褪黑素水平明显降低 (P <0 .0 1) ;女性的褪黑素水平略高于男性 (P <0 .0 5 ) ;健康老年人与老年患者 (主要为心血管系统疾病 )比较褪黑素水平差异无显著性意义(P >0 .0 5 ) ,年龄、性别和健康状况对白天血清褪黑素水平无明显影响。结论　年龄与性别是影响老年人夜间血清褪黑素水平的主要因素 ,研究结果未能显示健康状况对老年人血清褪黑素水平的影响。Objective To investigate serum melatonin (the hormone produced by pineal gland during the dark phase of circadian cycle) variations in Chinese elders.Method RIA was used to determine night(02:00) and morning(08:00) serum melatonin concentrations in 144 Chinese (31～110 years old).Results Night ( 02:00) serum melatonin levels showed decrease with aging and melatonin levels in 70s and >80s groups were significantly lower than that in <60s (P<0.01). Women had higher night serum melatonin levels than men had(P< 0.05).There were no significant differences(P>0.05)between healthy elders and patients (suffered mainly from cardiovascular diseases). Morning (08:00) serum melatonin levels showed no significant differences between different age, gender and healthy condition groups.Conclusion The results showed that both age and gender had significant influences on night (02:00) serum melatonin level,while failed to show any significant difference between healthy elders and patients.

关 键 词：褪黑激素 年龄因素 性别国素 心血管疾病 

分 类 号：R817.4[医药卫生—影像医学与核医学]