实验性草鱼胆中毒肾脏和肝脏损害的病理表现  

The pathologicl changes of renal and hepatic damage on rats caused by grass carp bile

作　　者：何敏 吴建新[2] 钮荣祥[2] 田昆仑[2] 潘云[3] 杨丽荣[3] 

机构地区：[1]大理学院内科教研室,云南大理671000 [2]大理学院生理病理生理教研室,云南大理671000 [3]大理学院病理教研室,云南大理671000

出　　处：《大理学院学报（综合版）》2003年第1期7-8,共2页Journal of Dali University

摘　　要：目的 :探讨实验性草鱼胆中毒的肝脏和肾脏病理变化 ,并探索药物治疗。方法 :将大白鼠分为正常对照组、模型组和药物组 ,均胃饲鱼胆汁 ,48h后取肾脏和肝脏行病理检查。结果 :草鱼胆中毒肾脏损害之病理表现为近曲小管上皮细胞变性、坏死 ,肾小球充血 ,肝细胞肿胀、变性、坏死 ;药物组和模型组的病理表现无明显差异。结论 :草鱼胆中毒肾脏损害病理表现为急性肾小管坏死 ,肾小球无明显异常 ;Objective:To study the pathological changes of renal and hepatic damage on rats caused by grass carp bile.Methods:To make the models of grass carp bile poisoning,take the kidey and liver for observation the pathological changes after48hours;Result:the pathological changes of kidney was the epithelial cells of proximal tubules swelling and necrotizing,the glomerulas fill with RBC in Bowmans space,hepatis cells was swelling and necrotizing;Conclusion:The renal damage by grass carp bile was mainly at the proximal tubules,the glomerule is normal generally.

关 键 词：实验性草鱼胆中毒 肾脏损害 肝脏损害 病理 

分 类 号：R996.1[医药卫生—毒理学]